GABA-A R beta 3 [p Ser409, p Ser408] Antibody

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. Phosphorylation of serine 408 and serine 409 within the beta-3 subunit have been shown to be critical for the functional modulation of beta-3 containing recombinant receptors (Brandon et al., 2000).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NBP2-29508	Applications	Species
Li Q, Li QQ, Jia JN et al. Sodium Valproate Ameliorates Neuronal Apoptosis in a kainic Acid Model of Epilepsy via Enhancing PkC-Dependent GABAAR g2 Serine 327 Phosphorylation. Neurochem. Res. 2018-10-11 [PMID: 30311181] (WB, Rat)	WB	Rat
Brewer AL, Liu S, Buhler AVK et al. Role of spinal GABA receptors in the acute antinociceptive response of mice to hyperbaric oxygen Brain Res. 2018-08-02 [PMID: 30077648] (WB, Mouse)	WB	Mouse
Bohnsack JP, Carlson SL, Morrow AL. Differential regulation of synaptic and extrasynaptic alpha4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons. Neuropharmacology 2016-06-01 [PMID: 26767953]

Array NBP2-29508

• GABA-A R beta 3 Antibodies
• GABA-A R beta 3 Lysates