E6AP/UBE3A Antibody (2F6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ICC/IF, IHC-Fr, WB.

Showing Publications 1 - 4 of 4.

Publications using H00007337-M01	Applications	Species
Sen D, Drobna Z, Keung AJ Evaluation of UBE3A antibodies in mice and human cerebral organoids Scientific reports 2021-03-18 [PMID: 33737669] (ICC/IF, WB, IHC-Fr, Mouse, Human)	ICC/IF, WB, IHC-Fr	Mouse, Human
Li S, Hong X, Wei Z et al. Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation Front Microbiol 2019-10-31 [PMID: 31749782] (WB, Human)	WB	Human
Spangle J, Ghosh-Choudhury N, Munger K. Activation of cap dependent translation by mucosal Human Papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif J Virol 2012-05-01 [PMID: 22553330] (WB, Human)	WB	Human
Underbrink MP, Howie HL, Bedard KM et al. The E6 proteins from multiple beta HPV types degrade Bak protect keratinocytes from apoptosis after UVB irradiation. J Virol;82(21):10408-17. 2008-11-01 [PMID: 18715924]

Array H00007337-M01

• E6AP/UBE3A Antibodies
• E6AP/UBE3A Lysate
• E6AP/UBE3A Proteins
• E6AP/UBE3A Proteins and Enzyme