G protein alpha Antibody

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Electron Microscopy, ICC/IF, Immunocytochemistry/ Immunofluorescence.

Showing Publications 1 - 3 of 3.

Publications using NBP1-49874	Applications	Species
Lucero Garcia Rojas EY Fusion Proteins as Selective Inducers of Constitutive Activity and Tools to Discriminate the Biased Signaling Profile of beta 2 Adrenoceptor Ligands Thesis 2022-01-01 (ICC/IF, Human)	ICC/IF	Human
Lucero-Garcia Rojas EY, Reyes-Alcaraz A, Ruan K et al. Fusion of the ?(2)-adrenergic receptor with either G?s or ?arrestin-2 produces constitutive signaling by each pathway and induces gain-of-function in BEAS-2B cells FASEB BioAdvances 2022-12-01 [PMID: 36479208] (Electron Microscopy, Immunocytochemistry/ Immunofluorescence)	Electron Microscopy, Immunocytochemistry/ Immunofluorescence
Nishihara E, Amino N, Maekawa K et al. Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan. Endocr J 2009-01-01 [PMID: 19550078]

Array NBP1-49874

• G protein alpha Antibodies
• G protein alpha Lysates
• G protein alpha Proteins