FOLR1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37‑42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown (1, 2). Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage (3‑6). Human FOLR1 shares 83% amino acid sequence identity with mouse and rat FOLR1. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas (7, 8). It is critically required during early embryogenesis as shown in knockout mice which die in utero with gross morphological defects (9). FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface (6, 10). A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk (11).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: ELISA Capture, ELISA Detection, Flow Cytometry, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using AF5646	Applications	Species
Naila Naz, Syeda F. Naqvi, Nadine Hohn, Kiara Whelan, Phoebe Littler, Federico Roncaroli et al. Cerebral Folate Metabolism in Post-Mortem Alzheimer’s Disease Tissues: A Small Cohort Study International Journal of Molecular Sciences 12/30/2022 [PMID: 36614107]
J Song, LJ Sokoll, DW Chan, Z Zhang Validation of Serum Biomarkers That Complement CA19-9 in Detecting Early Pancreatic Cancer Using Electrochemiluminescent-Based Multiplex Immunoassays Biomedicines, 2021-12-14;9(12):. 2021-12-14 [PMID: 34944713] (ELISA Capture, ELISA Detection, Human)	ELISA Capture, ELISA Detection	Human
A Nigro, L Frattaruol, M Fava, I De Napoli, M Greco, A Comandè, M De Santo, M Pellegrino, E Ricci, F Giordano, I Perrotta, A Leggio, L Pasqua, D Sisci, AR Cappello, C Morelli Bortezomib-Loaded Mesoporous Silica Nanoparticles Selectively Alter Metabolism and Induce Death in Multiple Myeloma Cells Cancers, 2020-09-21;12(9):. 2020-09-21 [PMID: 32967380] (Western Blot, Human)	Western Blot	Human
E Casta¤o, L Caviedes, S Hirsch, M Llanos, G I¤iguez, AM Ronco Folate Transporters in Placentas from Preterm Newborns and Their Relation to Cord Blood Folate and Vitamin B12 Levels PLoS ONE, 2017-01-19;12(1):e0170389. 2017-01-19 [PMID: 28103309] (Western Blot, Human)	Western Blot	Human
Puligujja P, McMillan J, Kendrick L et al. Macrophage Folate Receptor-Targeted Antiretroviral Therapy Facilitates Drug Entry, Retention, Antiretroviral Activities and Biodistribution for Reduction of Human Immunodeficiency Virus Infections. Nanomedicine 5/13/2013 [PMID: 23680933]
Rudman SM, Josephs DH, Cambrook H, Karagiannis P, Gilbert AE, Dodev T, Hunt J, Koers A, Montes A, Taams L, Canevari S, Figini M, Blower PJ, Beavil AJ, Nicodemus CF, Corrigan C, Kaye SB, Nestle FO, Gould HJ, Spicer JF, Karagiannis SN Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcvarepsilonRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity. Clin. Exp. Allergy, 2011-05-16;41(10):1400-1413. 2011-05-16 [PMID: 21569129] (Flow Cytometry, Human)	Flow Cytometry	Human

Array AF5646

• FOLR1 Antibodies
• FOLR1 Antibody Pair
• FOLR1 Lysates
• FOLR1 ELISAs
• FOLR1 Proteins and Enzymes