FGFR2 Antibody (133706) [Unconjugated] - (IIIc)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGF R1‑4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1‑3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha  isoform, or only IgII and IgIII, referred to as the beta  isoform. Only the alpha  isoform has been identified for FGF R3 and FGF R4. Additional splicing events for FGF R1‑3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGF R1. Mutations in FGF R1‑3 have been found in patients with birth defects involving craniosynostosis. The complex patterns of expression of these receptors as well as the specificity of their interactions with the various FGF ligand family members are under investigation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Bovine.

We have publications tested in 3 applications: IHC, IHC-P, Neutralization.

Showing Publications 1 - 5 of 5.

Publications using MAB716	Applications	Species
HL Devi, S Kumar, YY Konyak, J Bharati, A Bhimte, Y Pandey, K Kumar, A Paul, A Kala, HA Samad, MR Verma, G Singh, S Bag, M Sarkar, VS Chouhan Expression and functional role of fibroblast growth factors (FGF) in placenta during different stages of pregnancy in water buffalo (Bubalus bubalis) Theriogenology, 2019-11-29;143(0):98-112. 2019-11-29 [PMID: 31864010] (IHC-P, Bovine)	IHC-P	Bovine
DL Coutu, KD Kokkaliari, L Kunz, T Schroeder Multicolor quantitative confocal imaging cytometry Nat. Methods, 2017-11-13;15(1):39-46. 2017-11-13 [PMID: 29320487] (IHC, Mouse)	IHC	Mouse
K Nonogaki Treatment with FGFR2-IIIc monoclonal antibody suppresses weight gain and adiposity in KKA(y) mice Nutr Diabetes, 2016-11-28;6(11):e233. 2016-11-28 [PMID: 27892934] (Neutralization, Mouse)	Neutralization	Mouse
V. Shalhoub, S. C. Ward, B. Sun, J. Stevens, L. Renshaw, N. Hawkins et al. Fibroblast Growth Factor 23 (FGF23) and Alpha-Klotho Stimulate Osteoblastic MC3T3.E1 Cell Proliferation and Inhibit Mineralization Calcified Tissue International 2011-08-01 [PMID: 21633782]
Nakayama T, Mutsuga N, Tosato G FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood, 2006-10-31;109(4):1363-72. 2006-10-31 [PMID: 17077327] (Neutralization, Mouse)	Neutralization	Mouse

Array MAB716

• FGFR2 Antibodies
• FGFR2 Antibody Pair
• FGFR2 ELISA Kit
• FGFR2 Lysates
• FGFR2 Proteins