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FGFR2 alpha Antibody (98706)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
98706
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB6841-SP
Carrier Free
MAB6841-500
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FGFR2 alpha Antibody (98706) Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human FGF R2 isoforms and Mouse myeloma cell line NS0-derived recombinant human FGF R2 isoforms
Specificity
Detects human FGF R2 alpha in direct ELISAs and Western blots. Recognizes an epitope within the first Ig-like domain that is present only in  alpha isoforms of human FGF R2. Does not cross-react with  alpha isoforms of recombinant mouse FGF R2.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FGFR2
Purity
Protein A or G purified from ascites
Purity Statement
Protein A or G purified from ascites
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB6841 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from ascites
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FGFR2 alpha Antibody (98706)

  • BBDS;BEK;BFR-1;CD332;CEK3;CFD1;ECT1;Fibroblast growth factor receptor;Fibroblast growth factor receptor 2;JWS;KGFR;K-SAM;Receptor protein-tyrosine kinase;TK14;TK25
  • FGF R2a
  • FGFR2 alpha

Background

FGF activity is mediated by a family of type I transmembrane tyrosine kinases, which undergo dimerization and autophosphorylation after ligand binding. Five distinct genes encode closely related FGF receptors, FGF R1 through 5. FGF Rs contain three Ig-like domains and a stretch of acidic residues between the first and second Ig-like domains. FGF R1, 2, 3, and -4 have a cytoplasmic split tyrosine-kinase domain, but FGF R5 does not. Multiple forms of FGF R1, 2, and 3 are generated by alternative splicing

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FGFR2 alpha
Antibody (98706)
MAB6841
FGFR2 alpha Antibody (98706)
Species: Hu
Applications: WB

Publications for FGFR2 alpha Antibody (MAB6841)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: ICC/IF, IHC, IHC-P, Immunoprecipitation, Western Blot.


Filter By Application
ICC/IF
(1)
IHC
(1)
IHC-P
(2)
Immunoprecipitation
(1)
Western Blot
(3)
All Applications
Filter By Species
Human
(5)
All Species
Showing Publications 1 - 5 of 5.
Publications using MAB6841 Applications Species
T Shirakihar, H Yamaguchi, T Kondo, M Yashiro, R Sakai Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer Oncogene, 2022-03-25;0(0):. 2022-03-25 [PMID: 35338344] (ICC/IF, Western Blot, Human) ICC/IF, Western Blot Human
N Schäfer, GH Gielen, L Rauschenba, S Kebir, A Till, R Reinartz, M Simon, P Niehusmann, C Kleinschni, U Herrlinger, T Pietsch, B Scheffler, M Glas Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors J Transl Med, 2019-03-20;17(1):96. 2019-03-20 [PMID: 30894200] (IHC-P, Human) IHC-P Human
SY Kim, T Ahn, H Bang, JS Ham, J Kim, ST Kim, J Jang, M Shim, SY Kang, SH Park, BH Min, H Lee, WK Kang, KM Kim, W Park, J Lee Acquired resistance to LY2874455 in FGFR2-amplified gastric cancer through an emergence of novel FGFR2-ACSL5 fusion Oncotarget, 2017-02-28;8(9):15014-15022. 2017-02-28 [PMID: 28122360] (IHC-P, Human) IHC-P Human
Mathur , Anjili, Ware , Christop, Davis , Lenora, Gazdar , Adi, Pan , Bo-Sheng, Lutterbach , Bart FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival. PLoS ONE, 2014-06-26;9(6):e98515. 2014-06-26 [PMID: 24968263] (IHC, Western Blot, Human) IHC, Western Blot Human
Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A, Elbi C, Lutterbach B FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res., 2008-04-01;68(7):2340-8. 2008-04-01 [PMID: 18381441] (Immunoprecipitation, Western Blot, Human) Immunoprecipitation, Western Blot Human

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Bioinformatics

Gene Symbol FGFR2