FGF-10 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Fibroblast Growth Factors (FGFs) are heparin binding glycoproteins that exert a variety of biological activities toward cells of mesenchymal, neuronal, and epithelial origin. FGF-10 belongs to the subgroup of FGFs that also includes FGF-3, -7, and -22 (1). Mature mouse FGF-10 is an approximately 20 kDa protein that contains a serine-rich region near its N-terminus (2, 3). C-terminal to this region (aa 62‑209), it shares  94% and 100% amino acid sequence identity with human and rat FGF-10, respectively. FGF-10 is secreted by mesenchymal cells and associates with extracellular FGF-BP (1, 4). It preferentially binds and activates epithelial cell FGF R2 (IIIb) and interacts more weakly with FGF R1 (IIIb) (5). The mitogenic and chemotactic properties of FGF-10 are critical in many tissues during embryogenesis. This includes limb bud initiation (6), palate development (7), branching morphogenesis and directional outgrowth of lung buds (2, 8), formation of the otic vesicle and chochlea (9), adipogenesis (10), and the development of prostate, mammary, lacrimal, and submandibular salivary glands (11‑14). FGF R2 (IIIb) signaling in these responsive tissues is similarly important during embryogenesis (7, 9, 12‑14). The expression and function of FGF‑10 are negatively regulated by Shh and BMP-4 in the developing lung (2, 8). Overlapping expression patterns and activities with FGF-3, -7,  and -8 suggest at least a partial redundancy in FGF-10 biology (7, 9, 13, 14). FGF-10 induced signaling through FGF R2 (IIIb) also contributes to the progression of pancreatic cancer (15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF6224	Applications	Species
M Ishan, Z Wang, P Zhao, Y Yao, S Stice, L Wells, Y Mishina, HX Liu Taste papilla cell differentiation requires tongue mesenchyme via ALK3-BMP signaling to regulate the production of secretory proteins bioRxiv : the preprint server for biology, 2023-04-04;0(0):. 2023-04-04 [PMID: 37066397] (IHC, Mouse)	IHC	Mouse
K Zhang, VCH Lui, Y Chen, CN Lok, KKY Wong Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing Sci Rep, 2020-04-14;10(1):6338. 2020-04-14 [PMID: 32286492] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Y Chen, H Xu, G Lin Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse Cell Discov, 2017-12-19;3(0):17046. 2017-12-19 [PMID: 29263795] (IHC, Mouse)	IHC	Mouse
Wei Li, Chieh-Yu Lin, Ching Shang, Pei Han, Yiqin Xiong, Chien-Jung Lin et al. Pbx1 activates Fgf10 in the mesenchyme of developing lungs genesis 5/1/2014 [PMID: 24591256]

Array AF6224

• FGF-10 Antibodies
• FGF-10 Antibody Pair
• FGF-10 ELISA Kits
• FGF-10 Lysate
• FGF-10 Proteins
• FGF-10 Proteins and Enzymes