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FCRL3/FcRH3 Antibody (H5) [DyLight 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
H5
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

Order Details

FCRL3/FcRH3 Antibody (H5) [DyLight 405] Summary

Additional Information
Clone H5 was used by HLDA to establish CD designation.
Immunogen
DNA-immunization followed by a boost with FCRL3/FcRH3 transfected cells
Specificity
The mouse monoclonal antibody H5 recognizes an epitope within extracellular part of FCRL3/FcRH3, a transmembrane glycoprotein expressed mainly on NK cells, and T and B cell subsets.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
FCRL3
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for FCRL3/FcRH3 Antibody (H5) [DyLight 405]

  • CD307c
  • Fc receptor homolog 3
  • Fc receptor-like 3
  • Fc receptor-like protein 3
  • FcRH3
  • FCRL3
  • fcR-like protein 3
  • hIFGP3
  • IFGP3
  • immunoglobulin superfamily receptor translocation associated protein 3
  • IRTA3
  • SPAP2

Background

The FCRL3 gene codes for a member of the immunoglobulin receptor superfamily, a Fc receptor-like protein 3 that has seven isoforms: isoform 1: 734 amino acids long, 80 kDA; isoform 2: 639 amino acids long, nearly 70 kDA; isoform 3: 740 amino acids long, 81 kDA; isoform 4: 189 amino acids long, 21 kDA; isoform 5: 199 amino acids long, 22 kDA; isoform 6: 742 amino acid long, 81 kDA; and isoform 7: 707 amino acids long, 77 kDA. This protein functions in the moderation of the immune system as it obtains immunoreceptor-tyrosine activation motifs as well as immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain. It is known to interact with genes SYK, PTPN6, ZAP70, and PTPN11. FCRL3 is linked to multiple sclerosis, graves' disease, arthritis, lupus, rheumatoid arthritis, alopecia areata, behcet's disease, and primary biliary cirrhosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FCRL3