ER alpha/NR3A1 Antibody (681118)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ER alpha (Estrogen receptor alpha; also Estradiol receptor and NR3A1) is a 65-70 kDa member of the NR3 subfamily, nuclear hormone receptor family of proteins.  It is widely expressed, and serves as a strong activator of estrogen-responsive genes.  ER alpha is normally quiescent and bound to heat-shock proteins and immunophilins.  Following beta -estradiol binding, it becomes activated, either homodimerizes or heterodimerizes with ER beta , and binds to DNA with multiple coactivators.  Human ER alpha is 595 amino acids (aa) in length.  It contains a DNA binding region (aa 185-250), three NLSs (aa 256-260; 266-271; 299-303), a steroid-binding site (aa 351-543), a dimerization motif (aa 497-518), and an O-GlcNAc attachment around Thr575.  Major phosphorylation sites exist at Tyr537, Ser167 and Ser118.  Multiple splice forms exist.  There is an 80 kDa isoform that shows a substitution (duplication) of aa 412-517 for Asp411, a second isoform with a deletion of aa 255-366, a third isoform with a deletion of aa 152-412, and a fourth isoform that shows a Thr substitution for aa 152-595.  Human ER alpha is only 46% aa identical to human ER beta .  Over aa 1-116, human ER alpha shares 85% aa identity with mouse ER alpha .

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: IHC, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using MAB57151	Applications	Species
E Langille, KN Al-Zahrani, Z Ma, M Liang, L Uuskula-Re, R Espin, K Teng, A Malik, H Bergholtz, S El Ghamras, S Afiuni-Zad, R Tsai, S Alvi, A Elia, Y Lu, RH Oh, KJ Kozma, D Trcka, M Narimatsu, JC Liu, T Nguyen, S Barutcu, SK Loganathan, R Bremner, GD Bader, SE Egan, DW Cescon, T Sorlie, JL Wrana, HW Jackson, MD Wilson, AK Witkiewicz, ES Knudsen, MA Pujana, GM Wahl, D Schramek Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer Cancer Discovery, 2022-12-02;0(0):. 2022-12-02 [PMID: 36108220] (IHC, Mouse)	IHC	Mouse
M Li, A Jiang DNA methylation was involved in total glucosides of paeony regulating ERα for the treatment of female systemic lupus erythematosus mice J. Pharmacol. Sci., 2019-07-10;0(0):. 2019-07-10 [PMID: 31345653] (Western Blot, Mouse)	Western Blot	Mouse
Qin Zhou, Xixi Wu, Jianguo Hu, Rui Yuan Abnormal expression of fibrosis markers, estrogen receptor alpha and stromal derived factor‑1/chemokine (C‑X‑C motif) receptor‑4 axis in intrauterine adhesions International Journal of Molecular Medicine 3/22/2018 [PMID: 29568895]
Wang J, Jenkins S, Lamartiniere C Cell proliferation and apoptosis in rat mammary glands following combinational exposure to bisphenol A and genistein. BMC Cancer, 2014-05-29;14(0):379. 2014-05-29 [PMID: 24884420] (Western Blot, Rat)	Western Blot	Rat

Array MAB57151

• ER alpha/NR3A1 Antibodies
• ER alpha/NR3A1 Lysates
• ER alpha/NR3A1 Proteins
• ER alpha/NR3A1 ELISA