ER beta/NR3A2 Antibody (14C8)

The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domains have diverged significantly. Similar in function to ER-alpha, ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rabbit.

We have publications tested in 6 applications: Chemotaxis, ICC/IF, IF/IHC, IHC-P, IP, WB.

Showing Publications 1 - 10 of 78. Show All 78 Publications. Collapse Publications.

Publications using NB200-305	Applications	Species
Xue Wen, Yang Xiao, Haitao Xiao, Xueqin Tan, Beiyi Wu, Zehua Li, Ru Wang, Xuewen Xu, Tao Li Bisphenol S induces brown adipose tissue whitening and aggravates diet-induced obesity in an estrogen-dependent manner. Cell reports 2024-01-01 [PMID: 38041811]
Zhang X, Zhao P, Ma M et al. Missing link between tissue specific expressing pattern of ER? and the clinical manifestations in LGBLEL Frontiers in Medicine 2023-06-29 [PMID: 37457559]
Sun Y, Wang H, Wang W et al. Glutamatergic and GABAergic neurons in the preoptic area of the hypothalamus play key roles in menopausal hot flashes Frontiers in Aging Neuroscience 2022-10-14 [PMID: 36313017]
Liu M, Li H, Wang L et al. Cyanidin-3-o-glucoside pharmacologically inhibits tumorigenesis via estrogen receptor beta in melanoma mice Front Oncol 2019-10-22 [PMID: 31696058] (Human)		Human
Monteiro AC, Muenzner JK, Andrade F et al. Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis Proc. Natl. Acad. Sci. U.S.A. 2019-05-14 [PMID: 31040210] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Dubey, N, Hoffman, J F Et al. The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder. Mol Psychiatry 2017-08-01 [PMID: 28044059] (WB, Human)	WB	Human
Castelan F, Xelhuantzi N, Hernandez-Aragon LG et al. Morphometry of paravaginal ganglia from the pelvic plexus: impact of multiparity, primiparity, and pregnancy. Eur J Obstet Gynecol Reprod Biol 2013-08-06 [PMID: 23932302] (IHC-P, Rabbit)	IHC-P	Rabbit
Jardel P, Debiais C, Godet J, Irani J, Fromont G. Ductal Carcinoma Of The Prostate Shows A Different Immunophenotype From High Grade Acinar Cancer. Histopathology 2013-03-11 [PMID: 23701402] (IHC-P, Human)	IHC-P	Human
Lopez-Garcia K, E Cuevas, Corona-Quintanilla DL et al. Effect of multiparity on morphometry and oestrogen receptor expression of pelvic and perineal striated muscles in rabbits: is serum oestradiol relevant?. Eur J Obstet Gynecol Reprod Bio 2013-05-07 [PMID: 23664379] (IHC-P, Rabbit)	IHC-P	Rabbit
Kauffman EC, Robinson BD, Downes M et al. Estrogen receptor-beta expression and pharmacological targeting in bladder cancer. Oncol Rep 2013-07-01 [PMID: 23612777]
Verma Primate, Miki Y, Abe K et al. Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome. Life Sci 2012-10-01 [PMID: 22982181] (Chemotaxis, Human)	Chemotaxis	Human
Sato R, Suzuki T, Katayose Y et al. Aromatase in colon carcinoma. Anticancer Res 2012-08-01 [PMID: 22843875] (Chemotaxis, Human)	Chemotaxis	Human
Cheng L, Li J, Han Y et al. PES1 promotes breast cancer by differentially regulating ER alpha and ER beta J Clin Invest 2012-08-01 [PMID: 22820289] (IP, Chemotaxis, Human)	IP, Chemotaxis	Human
Karlsson C, Helenius G, Fernandes O et al. Oestrogen receptor B in NSCLC - prevalence, proliferative influence, prognostic impact and smoking. APMIS 2012-06-01 [PMID: 22583357] (Chemotaxis, Human)	Chemotaxis	Human
Tonetti DA, Gao W, Escarzaga D et al. PKC alpha and ERbeta Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients Int J Breast Cancer 2012-01-01 [PMID: 22500240] (IF/IHC, Human)	IF/IHC	Human
Zuguchi M, Miki Y, Onodera Y et al. Estrogen receptor a and B in esophageal squamous cell carcinoma. Cancer Sci 2012-07-01 [PMID: 22463081] (Chemotaxis, Human)	Chemotaxis	Human
Sase T, Suzuki T, Miura K et al. Runt-related transcription factor 2 (RUNX2) in human colon carcinoma: A potent prognostic factor associated with estrogen receptor. Int J Cancer. 2012-03-07 [PMID: 22396198] (Chemotaxis, Human)	Chemotaxis	Human
Verma Primate, Miki Y, Abe K et al. Cytoplasmic estrogen receptor B as a potential marker in human non-small cell lung carcinoma. Expert Opin Ther Targets 2012-03-01 [PMID: 22313325] (Chemotaxis, Human)	Chemotaxis	Human
Navaratnam S, Skliris G, Qing G et al. Differential role of estrogen receptor beta in early versus metastatic non-small cell lung cancer. Horm Cancer 2012-06-01 [PMID: 22302352] (Chemotaxis, Human)	Chemotaxis	Human
Choijamts B, Jimi S, Kondo T et al. CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Mullerian tumor). Stem Cells 2011-10-01 [PMID: 21919130] (Chemotaxis, Human)	Chemotaxis	Human
Honma N, Saji S, Hirose M et al. Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3B, 17B-diol. Cancer Sci 2011-10-01 [PMID: 21707867] (Chemotaxis, Human)	Chemotaxis	Human
Mehasseb Primate, Panchal R, Taylor AH et al. Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis. Fertil Steril 2011-06-01 [PMID: 21444077] (Chemotaxis, Human)	Chemotaxis	Human
Vouk K, Smuc T, Guggenberger C et al. Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis. J Steroid Biochem Mol Biol 2011-07-01 [PMID: 21397694] (Chemotaxis, Human)	Chemotaxis	Human
Miki Y, Abe K, Suzuki S et al. Suppression of estrogen actions in human lung cancer. Mol Cell Endocrinol 2011-07-01 [PMID: 21354461] (Chemotaxis, Human)	Chemotaxis	Human
Paruthiyil S, Cvoro A, Tagliaferri M et al. Estrogen receptor B causes a G2 cell cycle arrest by inhibiting CDk1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Breast Cancer Res Treat 2011-10-01 [PMID: 21120602] (Chemotaxis, Human)	Chemotaxis	Human
Huang GS, Gunter MJ, Arend RC et al. Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. Am J Obstet Gynecol 2010-09-01 [PMID: 20605134] (Chemotaxis, Human)	Chemotaxis	Human
Vivar OI, Zhao X, Saunier EF et al. Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem 2010-07-01 [PMID: 20404318] (Chemotaxis, Human)	Chemotaxis	Human
Mak P, Leav I, Pursell B et al. ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell 2010-04-01 [PMID: 20385358] (Chemotaxis, Human)	Chemotaxis	Human
Vivar OI, Saunier EF, Leitman DC et al. Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane. Endocrinology 2010-04-01 [PMID: 20160136] (Chemotaxis, Human)	Chemotaxis	Human
Koyama S, Wada-Hiraike O, Nakagawa S et al. Repression of estrogen receptor beta function by putative tumor suppressor DBC1 Biochem Biophys Res Commun 2010-02-12 [PMID: 20074560] (ICC/IF, Human)	ICC/IF	Human
Abe K, Miki Y, Ono K et al. Highly concordant coexpression of aromatase and estrogen receptor beta in non-small cell lung cancer. Hum Pathol 2010-02-01 [PMID: 19800101] (Chemotaxis, Human)	Chemotaxis	Human
Wong MH, Dobbins TA, Tseung J et al. Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland. J Clin Pathol 2009-09-01 [PMID: 19734474] (Chemotaxis, Human)	Chemotaxis	Human
Raso MG, Behrens C, Herynk MH et al. Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation. Clin Cancer Res 2009-09-01 [PMID: 19706809] (Chemotaxis, Human)	Chemotaxis	Human
Maehle BO, Collett K, Tretli S et al. Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer? APMIS 2009-09-01 [PMID: 19703124] (Chemotaxis, Human)	Chemotaxis	Human
Chakravarty D, Gupta N, Goda JS et al. Steroid receptors, HER2/neu and ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis. Acta Histochem 2010-07-01 [PMID: 19446313] (Chemotaxis, Human)	Chemotaxis	Human
Miki Y, Suzuki T, Nagasaki S et al. Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene. J Steroid Biochem Mol Biol 2009-02-01 [PMID: 19429434] (Chemotaxis, Human)	Chemotaxis	Human
Huang GS, Arend RC, Li M et al. Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. Am J Obstet Gynecol 2009-04-01 [PMID: 19200930] (Chemotaxis, Human)	Chemotaxis	Human
Sato R, Suzuki T, Katayose Y et al. Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors. Cancer Res 2009-02-01 [PMID: 19141651] (Chemotaxis, Human)	Chemotaxis	Human
Urbanska K, Pannizzo P, Lassak A et al. Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma. J Cell Physiol 2009-05-01 [PMID: 19117011] (Chemotaxis, Human)	Chemotaxis	Human
Belcher SM, Ma X, Le HH. Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma. Endocrinology 2009-03-01 [PMID: 19008315] (Chemotaxis, Human)	Chemotaxis	Human
Chakravarty D, Srinivasan R, Ghosh S et al. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol 2008-12-01 [PMID: 18931615] (Chemotaxis, Human)	Chemotaxis	Human
Setlur SR, Mertz KD, Hoshida Y et al. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst 2008-06-01 [PMID: 18505969] (Chemotaxis, Human)	Chemotaxis	Human
Ohata C, Tadokoro T, Itami SC316. Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas. J Dermatol 2008-04-01 [PMID: 18419678] (Chemotaxis, Human)	Chemotaxis	Human
Dohi O, Hatori M, Suzuki T et al. Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma. Cancer Sci 2008-03-01 [PMID: 18081879] (Chemotaxis, Human)	Chemotaxis	Human
Bukulmez O, Hardy DB, Carr BR et al. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology 2008-03-01 [PMID: 18048499] (Chemotaxis, Human)	Chemotaxis	Human
Caiazza F, Galluzzo P, Lorenzetti S et al. 17Beta-estradiol induces ERbeta up-regulation via p38/MAPk activation in colon cancer cells. Biochem Biophys Res Commun 2007-07-01 [PMID: 17524358] (Chemotaxis, Human)	Chemotaxis	Human
Gruvberger-Saal SK, Bendahl PO, Saal LH et al. Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Clin Cancer Res 2007-04-01 [PMID: 17404078] (Chemotaxis, Human)	Chemotaxis	Human
Galluzzo P, Caiazza F, Moreno S et al. Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. Endocr Relat Cancer 2007-03-01 [PMID: 17395984] (Chemotaxis, Human)	Chemotaxis	Human
Cvoro A, Paruthiyil S, Jones JO et al. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology 2007-02-01 [PMID: 17095596] (Chemotaxis, Human)	Chemotaxis	Human
Al-Dhaheri MH, Rowan BG et al. Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation. Mol Endocrinol 2007-02-01 [PMID: 17068199] (Chemotaxis, Human)	Chemotaxis	Human
Skliris GP, Lewis A, Emberley E et al. Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer. Breast Cancer Res Treat 2007-07-01 [PMID: 17009105] (Chemotaxis, Human)	Chemotaxis	Human
Dietrich W, Haitel A, Holzer G et al. Estrogen receptor-beta is the predominant estrogen receptor subtype in normal human synovia. J Soc Gynecol Investig 2006-10-01 [PMID: 16990033] (Chemotaxis, Human)	Chemotaxis	Human
Skliris GP, Leygue E, Curtis-Snell L et al. Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours. Br J Cancer 2006-09-01 [PMID: 16880783] (Chemotaxis, Human)	Chemotaxis	Human
Savinov AY, Remacle AG, Golubkov VS et al. Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients. Cancer Res 2006-03-01 [PMID: 16510592] (Chemotaxis, Human)	Chemotaxis	Human
Cvoro A, Tzagarakis-Foster C, Tatomer D et al. Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol Cell 2006-02-01 [PMID: 16483936] (Chemotaxis, Human)	Chemotaxis	Human
Poola I, Fuqua SA, De Witty RL et al. Estrogen receptor alpha-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERbeta1 and ERbeta5: potential molecular targets for chemoprevention. Clin Cancer Res 2005-10-01 [PMID: 16243834] (Chemotaxis, Human)	Chemotaxis	Human
Schwartz AG, Prysak GM, Murphy V et al. Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex. Clin Cancer Res 2005-10-01 [PMID: 16243798] (Chemotaxis, Human)	Chemotaxis	Human
Poola I, Abraham J, Baldwin K et al. Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization. Endocrine 2005-08-01 [PMID: 16230778] (Chemotaxis, Human)	Chemotaxis	Human
Zheng FF, Wu RC, Smith CL et al. Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor. Mol Cell Biol 2005-09-01 [PMID: 16135815] (Chemotaxis, Human)	Chemotaxis	Human
Ishibashi H, Suzuki T, Suzuki S et al. Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy. Cancer Res 2005-07-01 [PMID: 16024650] (Chemotaxis, Human)	Chemotaxis	Human
Helguero LA, Faulds MH, Gustafsson JA et al. Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene 2005-10-01 [PMID: 16007178] (Chemotaxis, Human)	Chemotaxis	Human
Miki Y, Suzuki T, Tazawa C et al. Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett 2005-04-01 [PMID: 15766595] (Chemotaxis, Human)	Chemotaxis	Human
Jones LP, Li M, Halama ED et al. Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene 2005-05-01 [PMID: 15750629] (Chemotaxis, Human)	Chemotaxis	Human
Hopp TA, Weiss HL, Parra IS et al. Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer. Clin Cancer Res 2004-11-01 [PMID: 15569979] (Chemotaxis, Human)	Chemotaxis	Human
Balfe P, McCann A, McGoldrick A et al. Estrogen receptor alpha and beta profiling in human breast cancer. Eur J Surg Oncol 2004-06-01 [PMID: 15135471] (Chemotaxis, Human)	Chemotaxis	Human
Speirs V, Carder PJ, Lane S et al. Oestrogen receptor beta: what it means for patients with breast cancer. Lancet Oncol 2004-03-01 [PMID: 15003201] (Chemotaxis, Human)	Chemotaxis	Human
Paruthiyil S, Parmar H, Kerekatte V et al. Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res 2004-01-01 [PMID: 14729654] (Chemotaxis, Human)	Chemotaxis	Human
Tee Primate, Rogatsky I, Tzagarakis-Foster C et al. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell 2004-03-01 [PMID: 14699072] (Chemotaxis, Human)	Chemotaxis	Human
Tonetti DA, Rubenstein R, DeLeon M et al. Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells. J Steroid Biochem Mol Biol 2003-10-01 [PMID: 14630090] (Chemotaxis, Human)	Chemotaxis	Human
Skliris GP, Munot K, Bell SM et al. Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model. J Pathol 2003-10-01 [PMID: 14517838] (Chemotaxis, Human)	Chemotaxis	Human
Li XQ, Hisaoka M, Hashimoto H et al. Expression of estrogen receptors alpha and beta in soft tissue sarcomas: Immunohistochemical and molecular analysis. Pathol Int 2003-10-01 [PMID: 14516317] (Chemotaxis, Human)	Chemotaxis	Human
Omoto Y, Eguchi H, Yamamoto-Yamaguchi Y et al. Estrogen receptor (ER) beta1 and ERbetacx/beta2 inhibit ERalpha function differently in breast cancer cell line MCF7. Oncogene 2003-08-01 [PMID: 12902984] (Chemotaxis, Human)	Chemotaxis	Human
Fuqua SA, Schiff R, Parra I et al. Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res 2003-05-01 [PMID: 12750263] (Chemotaxis, Human)	Chemotaxis	Human
Linja MJ, Savinainen KJ, Tammela TL et al. Expression of ERalpha and ERbeta in prostate cancer. Prostate 2003-05-01 [PMID: 12692783] (Chemotaxis, Human)	Chemotaxis	Human
Saji S, Omoto Y, Shimizu C et al. Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor. Cancer Res 2002-09-01 [PMID: 12208729] (IF/IHC, Human)	IF/IHC	Human
Skliris GP, Parkes AT, Limer JL et al. Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue. J Pathol 2002-06-01 [PMID: 12015738] (Chemotaxis, Human)	Chemotaxis	Human
Speirs V, Skliris GP, Burdall SE & Carder PJ. Distinct expression patterns of ERa and ERb in normal human mammary gland. J Clin Path, in press. 2002-01-01 [PMID: 11986344]
Skliris GP, Carder PJ, Lansdown MRJ, Speirs V. Immunohistochemical detection of ER-Beta in breast cancer: towards more detailed receptor profiling? Brit. J of Can 84:1095-1098. 2001-01-01 [PMID: 11308260]
Show All 78 Publications. Collapse Publications.

Array NB200-305

• ER beta/NR3A2 Antibodies
• ER beta/NR3A2 ELISA Kits
• ER beta/NR3A2 Lysates
• ER beta/NR3A2 Protein