eIF2 alpha/EIF2S1 Antibody

EIF2S1, also known as eIF2a, is the alpha subunit of the translation initiation factor eIF2 complex which catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. The phosphorylation state of eIF2S1 controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2S1 is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation. Recombinant human EIF2S1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using NB100-2249	Applications	Species
Qin Q, Hastings C, Miller CL et al. Mammalian orthoreovirus particles induce and are recruited into stress granules at early times postinfection. J Virol 2009-11-01 [PMID: 19710141]

Array NB100-2249

• eIF2 alpha/EIF2S1 Antibodies
• eIF2 alpha/EIF2S1 Lysate
• eIF2 alpha/EIF2S1 Proteins