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DUOX2 Antibody [PE]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, CaSpecies Glossary
Applications WB, ICC/IF, IHC, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
PE

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DUOX2 Antibody [PE] Summary

Immunogen
Synthetic peptide made to an internal portion of human DUOX2 (within residues 400-500). [Swiss-Prot# Q9NRD8]
Localization
Apical cell membrane; Multi-pass membrane protein. Note: Localizes to the apical membrane of epithelial cells.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DUOX2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for DUOX2 Antibody [PE]

  • dual oxidase 2
  • dual oxidase-like domains 2
  • EC 1.11.1.-
  • EC 1.6.3.1
  • flavoprotein NADPH oxidase
  • Large NOX 2
  • LNOX2P138(TOX)
  • Long NOX 2
  • NADH/NADPH thyroid oxidase p138-tox
  • NADPH oxidase/peroxidase DUOX2
  • NADPH thyroid oxidase 2
  • nicotinamide adenine dinucleotide phosphate oxidase
  • NOXEF2
  • p138 thyroid oxidase
  • P138-TOX
  • THOX2TDH6
  • Thyroid oxidase 2

Background

Dual oxidase 2 (DUOX2), a reduced NAD phosphate:O2 oxidoreductase flavoprotein, plays a critical role in the synthesis of thyroid hormones by providing thyroperoxidase with hydrogen peroxide, which is required for hormone synthesis at the apical plasma membrane. The discovery of DUOX-2 as a novel source of hydrogen peroxide in the digestive tract, particularly in the cecum and colon, makes it a new candidate mediator of physiopathological processes.

DUOX2 antibodies may be useful tools for thyroid hormone synthesis, hormonal regulation disorders, and certian types of cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for DUOX2 Antibody (NB110-61576PE). (Showing 1 - 1 of 1 FAQ).

  1. Hi, I am looking for an antibody to human DUOX2 that will work on human formalin fixed paraffin embedded sections. I notice from your website that you have several recommended for WB and wondered if you have any experience of their use in other areas?
    • At this time we do not have an antibody for DUOX2 that works in IHC paraffin embedded sections. If you choose to try one in this application we have our Innovator's Reward program where we reward our customers for trying antibodies in previously untested applications and species.

Secondary Antibodies

 

Isotype Controls

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Research Areas for DUOX2 Antibody (NB110-61576PE)

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Blogs on DUOX2.

Toll-like receptors in the intestinal epithelial cells
By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria ...  Read full blog post.

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Bioinformatics

Gene Symbol DUOX2