Dkk-2 Antibody

Analysis of individual DKK domains and chimeric DKKs shows that the carboxy-terminal domains of both DKK1 and DKK2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. Xenopus Dickkopf 1 (DKK1) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of DKK have been identified in mammals. Each DKK molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of DKK1 and DKK2 inhibited Wnt3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of DKK2, but not that of DKK1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB300-810	Applications	Species
Krupnik VE, Sharp JD, Jiang C et al. Functional and structural diversity of the human Dickkopf gene family. Gene 1999-10-01 [PMID: 10570958]

Array NB300-810

• Dkk-2 Antibodies
• Dkk-2 ELISA Kits
• Dkk-2 Lysate
• Dkk-2 Protein
• Dkk-2 Proteins and Enzymes