Species: Mu
Applications: WB, IHC
Host: Goat Polyclonal
Species: Hu
Applications: IHC, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Bioactivity
Species: Hu
Applications: AC
Description
Analysis of individual DKK domains and chimeric DKKs shows that the carboxy-terminal domains of both DKK1 and DKK2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. Xenopus Dickkopf 1 (DKK1) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of DKK have been identified in mammals. Each DKK molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of DKK1 and DKK2 inhibited Wnt3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of DKK2, but not that of DKK1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.
Bioinformatics
Entrez |
Human |
Uniprot |
Human Human Human |
Product By Gene ID |
27123 |
Alternate Names |
- dickkopf (Xenopus laevis) homolog 2
- dickkopf 2
- dickkopf homolog 2 (Xenopus laevis)
- dickkopf related protein-2
- dickkopf-2
- Dickkopf-2
- dickkopf-related protein 2
- DKK-2
- Dkk-2
- hDkk-2
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