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DIO2 Antibody

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Western Blot: DIO2 Antibody [NBP2-84790] - Host: Rabbit. Target Name: DIO2. Sample Tissue: ACHN Whole Cell lysates. Antibody Dilution: 1ug/ml
Western Blot: DIO2 Antibody [NBP2-84790] - Host: Rat. Target Name: DIO2. Sample Tissue: Rat Skeletal Muscle. Antibody Dilution: 1ug/ml

Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

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DIO2 Antibody Summary

Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human DIO2. Peptide sequence: ILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDA The peptide sequence for this immunogen was taken from within the described region.
Clonality
Polyclonal
Host
Rabbit
Gene
DIO2
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1.0 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Affinity purified

Alternate Names for DIO2 Antibody

  • 5DII
  • D2
  • deiodinase, iodothyronine, type II
  • DIOII
  • EC 1.97.1
  • EC 1.97.1.10
  • ITDI2
  • SelY
  • TXDI2thyroxine deiodinase, type II
  • Type 2 DI
  • type 2 iodothyronine deiodinase
  • type II iodothyronine deiodinase
  • type-II 5'deiodinase
  • Type-II 5'-deiodinase

Background

DIO2 is encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol DIO2