DC-SIGN/CD209 Antibody (109H12.03)

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

DC-SIGN encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 8 of 8.

Publications using DDX0207	Applications	Species
Gabriel-Segard T, Rontard J, Miny L et al. Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases International Journal of Molecular Sciences 2023-06-24 [PMID: 37445748] (ICC/IF)	ICC/IF
Debeer S et al. Comparative histology and immunohistochemistry of porcine versus human skin. Eur J Dermatol 2013-07-01 [PMID: 24047577]
Rochereau N et al. Phenotypic localization of distinct DC subsets in mouse Peyer Patch. Vaccine 2011-05-09 [PMID: 21439318]
Canard B et al. Generation of anti-DC-SIGN monoclonal antibodies capable of blocking HIV-1 gp120 binding and reactive on formalin-fixed tissue. Immunol Lett 2011-03-01 [PMID: 21078343]
Kwan WH et al. Dermal-type macrophages expressing CD209/DC-SIGN show inherent resistance to dengue virus growth. PLoS Negl Trop Dis 2008-10-01 [PMID: 18827881]
Dakappagari N et al. Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses. J Immunol 2006-01-01 [PMID: 16365436]
Soilleux EJ et al. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe. Clin Sci (Lond) 2003-04-01 [PMID: 12653690]
Bashirova AA et al. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J Exp Med 2001-03-01 [PMID: 11257134]

Array DDX0207

• DC-SIGN/CD209 Antibodies
• DC-SIGN/CD209 Antibody Pair
• DC-SIGN/CD209 ELISA Kit
• DC-SIGN/CD209 Lysate
• DC-SIGN/CD209 Proteins
• DC-SIGN/CD209 Proteins and Enzymes