Home » CXCL10/IP-10/CRG-2 » CXCL10/IP-10/CRG-2 Antibodies » CXCL10/IP-10/CRG-2 Antibody [Unconjugated]
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CXCL10/IP-10/CRG-2 Antibody [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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CXCL10/IP-10/CRG-2 Antibody [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human CXCL10/IP-10
Specificity
Detects human CXCL-10/IP-10/CRG-2 in direct ELISAs and Western blots. In direct ELISAs, this antibody shows less than 1% cross‑reactivity with rhENA-78, rhGRO alpha , rhGRO beta , rhGRO gamma , rhI‑309, rmJE, rhMCP-1, rhMIP‑1 alpha , rmMIP‑1 alpha , rhMIP-1 beta , rmMIP-1 beta , and rhRANTES.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CXCL10
Purity Statement
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Reviewed Applications
Read 1 Review rated 5
using
AB-266-PB in the following application:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 1 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL10/IP-10/CRG-2 Antibody [Unconjugated]

  • C7
  • chemokine (C-X-C motif) ligand 10
  • CRG2
  • CRG-2
  • CXCL10
  • gIP-10
  • IFI10
  • INP10
  • IP-10
  • mob-1
  • SCYB10

Background

CXCL10 was originally identified as an IFN-gamma -inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that CXCL10 mRNA is also induced by LPS, IL-1 beta , TNF-alpha , IL-12 and viruses. Additional cell types that have been shown to express CXCL10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. CXCL10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human CXCL10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human CXCL10. Human CXCL10 cDNA encodes a 98 amino acid (aa) residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted protein. The amino acid sequence of CXCL10 identified the protein as a member of the chemokine alpha subfamily that lacks the ELR domain. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes. CXCL10 has been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent antitumor effect. A chemokine receptor specific for CXCL10 and Mig has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.
  1. Loetscher, M. et al. (1996) J. Exp. Med. 184:963.
  2. Wang, X. et al .(1996) J. Biol. Chem. 271:24286.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCL10/IP-10/CRG-2 Antibody (AB-266-PB) (0)

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Review for CXCL10/IP-10/CRG-2 Antibody (AB-266-PB) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using AB-266-PB:
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WB
(1)
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Images Ratings Applications Species Date Details
  5
reviewed by:
Verified Customer
 WB Human 01/05/2015
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Summary

ApplicationWestern Blot
Sample TestedSee PMID 19552626
SpeciesHuman

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Application: WB
Species: Human
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Bioinformatics

Gene Symbol CXCL10