Home » CXCL10/IP-10/CRG-2 » CXCL10/IP-10/CRG-2 Antibodies » CXCL10/IP-10/CRG-2 Antibody (1050502) [Unconjugated]
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CXCL10/IP-10/CRG-2 Antibody (1050502) [Unconjugated]

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CXCL10/IP-10/CRG-2 was detected in immersion fixed mIMCD3 (positive) or C2C12 (negative) mouse cell line using Rat Anti-Mouse CXCL10/IP-10/CRG-2 Monoclonal Antibody (Catalog # MAB4661) at 3 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red; NL013) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. Staining was performed using our protocol for Fluorescent ICC Staining of Adherent Cells.
CXCL10/IP-10/CRG-2 was detected in immersion fixed mIMCD3 (positive) or C2C12 (negative) mouse cell line using Rat Anti-Mouse CXCL10/IP-10/CRG-2 Monoclonal Antibody (Catalog # MAB4661) at 3 µg/mL for 3 hours at room ...read more
CXCL10/IP-10/CRG-2 was detected in immersion fixed paraffin-embedded sections of Mouse Thymus using Rat Anti-Mouse CXCL10/IP-10/CRG-2 Monoclonal Antibody (Catalog # MAB4661) at 15 µg/mL for 1 hour at room temperature ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications IHC, ICC/IF
Clone
1050502
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB4661-SP
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CXCL10/IP-10/CRG-2 Antibody (1050502) [Unconjugated] Summary

Immunogen
E. coli-derived mouse CXCL10/IP-10/CRG-2 protein
Ile22-Pro98
Accession # Q548V9
Specificity
Detects mouse CXCL10/IP-10/CRG-2 in direct and capture Elisas.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunocytochemistry 3-25 ug/mL
  • Immunohistochemistry 3-25 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL10/IP-10/CRG-2 Antibody (1050502) [Unconjugated]

  • C7
  • chemokine (C-X-C motif) ligand 10
  • CRG2
  • CRG-2
  • CXCL10
  • gIP-10
  • IFI10
  • INP10
  • IP-10
  • mob-1
  • SCYB10

Background

The gene for CRG-2, a mouse homolog of human IP-10, was originally identified as an immediate early gene induced in response to macrophage activation. It has since been shown that CRG-2 mRNA is induced by alpha / beta / gamma -interferons and by lipopolysaccharide in macrophages, astrocytes and microglia. Human IP-10 was also shown to be expressed in activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. Mouse CRG-2 cDNA encodes a 98 amino acid (aa) residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted mature protein. Mature CRG-2 shares approximately 67% amino acid sequence identity with human IP-10. The amino acid sequence of CRG-2 identified the protein as a member of the chemokine alpha subfamily that lacks the ELR domain. CRG-2 has been shown to be a chemoattractant for activated T-lymphocytes. Recently, human IP-10 has also been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent anti-tumor effect. A chemokine receptor specific for IP-10 and MIG (CXCR3) has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.
  1. Loetscher, M. et al. (1996) J. Exp. Med. 184:963.
  2. Vanguri, P. (1996) J. Neuroimmunol. 56:35.
  3. Sgadari, C. et al. (1996) Blood, 87:3877.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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