COX4 Antibody (673803) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

COX4-I2 (Cytochrome c oxidase subunit 4) is a 21-22 kDa member of the Cytochrome c oxidase IV family of proteins and is predominantly expressed in lung. It is a component of COX, an inner mitochondrial membrane multimeric dimer that catalyzes the transfer of electrons from Cytochrome c to dioxygen. COX4-I2 is induced following blockade of mitochondrial respiration, leading to increased production of reactive oxygen species and necrosis. The ubiquitously expressed COX4-I1 is the product of a different gene and shares only 50% aa identity with COX4-I2. Within aa 39-171 (the oxidase domain), human COX4-I2 shares 84% and 81% aa sequence identity with mouse and rat COX4-I2, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IHC-P, Immunohistochemistry, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using MAB6980	Applications	Species
En, A;Bogireddi, H;Thomas, B;Stutzman, A;Ikegami, S;LaForest, B;Almakki, O;Pytel, P;Moskowitz, I;Ikegami, K; Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice Cell Reports 2024-05-29 [PMID: 38814785] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
JH Lee, M Hussain, EW Kim, SJ Cheng, AKL Leung, NB Fakouri, DL Croteau, VA Bohr Mitochondrial PARP1 regulates NAD+-dependent poly ADP-ribosylation of mitochondrial nucleoids Experimental & Molecular Medicine, 2022-12-06;0(0):. 2022-12-06 [PMID: 36473936] (Western Blot, Human)	Western Blot	Human
Junnan Wu, Ziyuan Ma, Archana Raman, Pazit Beckerman, Poonam Dhillon, Dhanunjay Mukhi et al. APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis Immunity 11/1/2021 [PMID: 34715018]
X Ma, F Cheng, K Yuan, K Jiang, T Zhu Lipid storage droplet protein 5 reduces sodium palmitate?induced lipotoxicity in human normal liver cells by regulating lipid metabolism?related factors Mol Med Rep, 2019-06-06;20(2):879-886. 2019-06-06 [PMID: 31173228] (Western Blot, Human)	Western Blot	Human
D Kurundkar, AR Kurundkar, NB Bone, EJ Becker, W Liu, B Chacko, V Darley-Usm, JW Zmijewski, VJ Thannickal SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury JCI Insight, 2019-01-10;4(1):. 2019-01-10 [PMID: 30626741] (IHC-P, Mouse)	IHC-P	Mouse
E Britti, F Delaspre, A Feldman, M Osborne, H Greif, J Tamarit, J Ros Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment J. Cell. Mol. Med., 2017-10-05;0(0):. 2017-10-05 [PMID: 28980774] (Western Blot, Human)	Western Blot	Human

Array MAB6980

• COX4 Antibodies
• COX4 Lysate
• COX4 Proteins