COX-2 Antibody (495222) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cyclooxygenase-2 (COX-2) also known as prostaglandin G/H synthase 2 (PGHS2) is a 70 kDa microsomal enzyme that belongs to the prostaglandin G/H synthase family. It is inducibly-expressed by a number of cell types, including fibroblasts, vascular smooth muscle cells, endothelium, and monocytes. Functionally, COX-2 is a homodimer that catalyzes two steps in the conversion of arachadonic acid to prostaglandin H2. Mature human COX-2 is 587 amino acids (aa) in length and contains one EGF-like domain (aa 18‑55), a potential membrane interacting region (aa 277‑292) and a globular catalytic domain (aa 293‑604). At least one splice form exists that shows an 11 aa substitution for the C-terminal 451 amino acids. Over the amino acid range of the immunogen, human COX-2 shows 83% aa identity to mouse COX-2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Western Blot, Western Blots.

Showing Publications 1 - 5 of 5.

Publications using MAB4198	Applications	Species
María Piñeiro-Ramil, Elena F. Burguera, Tamara Hermida-Gómez, Beatriz Caramés, Natividad Oreiro-Villar, Rosa Meijide-Faílde et al. Reduced Levels of H2S in Diabetes-Associated Osteoarthritis Are Linked to Hyperglycaemia, Nrf-2/HO-1 Signalling Downregulation and Chondrocyte Dysfunction Antioxidants (Basel) 3/25/2022 [PMID: 35453313]
M Apweiler, J Streyczek, SW Saliba, JA Collado, T Hurrle, S Grä beta le, E Muñoz, C Normann, S Hellwig, S Bräse, BL Fiebich Functional Selectivity of Coumarin Derivates Acting via GPR55 in Neuroinflammation International Journal of Molecular Sciences, 2022-01-16;23(2):. 2022-01-16 [PMID: 35055142] (Western Blots, Human)	Western Blots	Human
G Kaufman, D Skrtic N-Acetyl Cysteine Modulates the Inflammatory and Oxidative Stress Responses of Rescued Growth-Arrested Dental Pulp Microtissues Exposed to TEGDMA in ECM Int J Mol Sci, 2020-10-03;21(19):. 10/3/2020 [PMID: 33023018]
G Qiu, G Zheng, M Ge, L Huang, H Tong, P Chen, D Lai, Y Hu, B Cheng, Q Shu, J Xu Adipose-derived mesenchymal stem cells modulate CD14(++)CD16(+) expression on monocytes from sepsis patients in vitro via prostaglandin E2 Stem Cell Res Ther, 2017-04-26;8(1):97. 2017-04-26 [PMID: 28446249] (Western Blot, Human)	Western Blot	Human
C Herz, HT Tran, MR Márton, R Maul, S Baldermann, M Schreiner, E Lamy Evaluation of an Aqueous Extract from Horseradish Root (Armoracia rusticana Radix) against Lipopolysaccharide-Induced Cellular Inflammation Reaction Evid Based Complement Alternat Med, 2017-01-15;2017(0):1950692. 2017-01-15 [PMID: 28182113] (Western Blot, Human)	Western Blot	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	IHC-P	Human	01/16/2020	View Summary Application Immunohistochemistry-Paraffin Sample Tested Human Tonsil tissue Species Human Lot CBLK0116091 Comments Comments pH 9 antigen retrieval

Array MAB4198

• COX-2 Antibodies
• COX-2 Protein
• COX-2 ELISA
• COX-2 Proteins and Enzyme