COPR5 Antibody

COPR5 is a Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that COPR5 acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: B/N, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP2-30884	Applications	Species
Mulvaney KM, Blomquist C, Acharya N Et al. Molecular basis for substrate recruitment to the PRMT5 methylosome Molecular cell 2021-07-28 [PMID: 34358446] (B/N)	B/N
Wegscheid Ml, Anastasaki C, Hartigan Ka Et Al. Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis Cell reports 2021-07-06 [PMID: 34233200] (WB)	WB
Strahan RC, McDowell-Sargent M, Uppal T et al. KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation PLoS Pathog. 2017-07-01 [PMID: 28678843] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Human and Mouse	10/17/2019	View Summary Application Western Blot Sample Tested HEK 293 cell line,Hela whole cell lysate,Human glioma U87 Cell,Mouse brain Species Human and Mouse Lot A118309

Array NBP2-30884

• COPR5 Antibody
• COPR5 ELISA Kits
• COPR5 Lysate
• COPR5 Protein