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Common gamma Chain/IL-2 R gamma Antibody (633162) [Unconjugated]

 (5 Publications)
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Human peripheral blood lymphocytes were stained with Mouse Anti-Human Common gamma Chain/IL‑2 R gamma Monoclonal Antibody (Catalog # MAB2842, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2 Secondary Antibody (Catalog # F0101B).
Human peripheral blood lymphocytes were stained with Mouse Anti-Human Common gamma Chain/IL‑2 R gamma Monoclonal Antibody (Catalog # MAB2842, filled histogram) or isotype control antibody (Catalog # MAB0041, open ...read more
Recombinant Human IL‑2 (Catalog # 202-IL) stimulates proliferation in the MO7e human megakaryocytic leukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recom­binant Human IL‑2 ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, B/N, CyTOF-ready
Clone
633162
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB2842U-100UG
Alexa Fluor 405
FAB2842V-100UG
Alexa Fluor 488
FAB2842G-100UG
Alexa Fluor 532
FAB2842X
Alexa Fluor 594
FAB2842T-100UG
Alexa Fluor 647
FAB2842R-100UG
Alexa Fluor 700
FAB2842N-100UG
Alexa Fluor 750
FAB2842S-100UG
Allophycocyanin
FAB2842A
Allophycocyanin/Cy7
FAB2842APCCY7
Biotin
FAB2842B
DyLight 350
FAB2842D
DyLight 405
FAB2842E
DyLight 488
FAB2842K
DyLight 550
FAB2842L
DyLight 594
FAB2842M
DyLight 650
FAB2842W
DyLight 680
FAB2842Y
DyLight 755
FAB2842Z
HRP
FAB2842H
Janelia Fluor 549
FAB2842I
Janelia Fluor 646
FAB2842J
PE/Atto594
FAB2842PEATT594
PE/Cy5.5
FAB2842PECY55
PE/Cy7
FAB2842PECY7
PerCP
FAB2842C
mFluor Violet 450 SE
FAB2842MFV450
mFluor Violet 500 SE
FAB2842MFV500
mFluor Violet 610 SE
FAB2842MFV610
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
FAB2842A
Carrier Free
MAB2842-SP
Carrier Free
FAB2842V-100UG
Carrier Free
FAB2842U-100UG
Carrier Free
FAB2842T-100UG
Carrier Free
FAB2842S-100UG
Carrier Free
FAB2842R-100UG
Carrier Free
FAB2842N-100UG
Carrier Free
FAB2842G-100UG
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Common gamma Chain/IL-2 R gamma Antibody (633162) [Unconjugated] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf21-derived recombinant human Common gamma Chain/IL-2 gamma
Leu23-Asn254
Accession # P31785
Specificity
Detects human Common gamma Chain/IL-2 R gamma in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R alpha , rhIL-2 R beta , rhIL-15 R alpha , recombinant mouse IL-2 R gamma , or recombinant canine IL-2 R alpha is observed. In Western blots, approximately 80% cross-reactivity with recombinant human IL-2 R beta , 50% cross-reactivity with rhIL-15 R alpha and recombinant mouse IL-2 R alpha , and no cross-reactivity with rhIL-2 R alpha is observed.
Details of Functionality
None<br /><br />None<br /><br />
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
IL2RG
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.100 EU per 1 µg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 2.5 ug/10^6 cells
  • Neutralization 0.08-0.4 ug/mL
Publications
Read Publications using
MAB2842 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL. For liquid material, refer to CoA for concentration.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Common gamma Chain/IL-2 R gamma Antibody (633162) [Unconjugated]

  • CD132 antigen
  • CD132
  • CIDX
  • combined immunodeficiency, X-linked
  • common cytokine receptor gamma chain
  • Common gamma Chain
  • common gamma-chain
  • cytokine receptor common subunit gamma
  • gamma(c)
  • IL-2 R gamma
  • IL-2 receptor subunit gamma
  • IL2R gamma
  • IL-2R subunit gamma
  • IL2RG
  • IL-2RG
  • IMD4
  • interleukin 2 receptor, gamma
  • Interleukin-2 receptor subunit gamma
  • P64
  • SCIDX
  • SCIDX1
  • severe combined immunodeficiency

Background

The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid protein consisting of a 22 aa signal sequence, a 232 aa extracellular domain, a 29 aa transmembrane domain and an 86 aa cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL‑2 with any appreciable affinity, it is required for IL-2 receptor signaling. Besides IL-2, the gamma  chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15. IL-2 R gamma has been designated the common gamma chain ( gamma c). The site of molecular defects in X-linked SCID (severe combined immunodeficiency) has been mapped to the IL-2 R gamma gene.

  1. Minami, Y. et al. (1993) Annu. Rev. Immunol. 11:245.
  2. Noguchi, M. et al. (1993) Science 262:1877.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Common gamma Chain/IL-2 R gamma Antibody (MAB2842)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, Neutralization.


Filter By Application
Flow Cytometry
(1)
Neutralization
(3)
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Human
(4)
All Species
Showing Publications 1 - 5 of 5.
Publications using MAB2842 Applications Species
Wu, WC;Shiu, C;Tong, TK;Leung, SO;Hui, CW; Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases Journal of immunology research 2023-12-08 [PMID: 38106519] (Neutralization, Human) Neutralization Human
Aurore Devocelle, Lola Lecru, Hélène François, Christophe Desterke, Cindy Gallerne, Pierre Eid et al. Inhibition of TGF-beta 1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-beta 1-Induced EMT in Renal Fibrosis International Journal of Cell Biology 2019-07-07 [PMID: 31360169]
Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling Sci Rep, 2016-09-02;6(0):32320. 2016-09-02 [PMID: 27586092] (Flow Cytometry, Human) Flow Cytometry Human
Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA Antigen-independent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J. Immunol., 2012-03-14;188(8):3745-56. 2012-03-14 [PMID: 22422881] (Neutralization, Human) Neutralization Human
Giron-Michel J, Azzi S, Khawam K, Mortier E, Caignard A, Devocelle A, Ferrini S, Croce M, Francois H, Lecru L, Charpentier B, Chouaib S, Azzarone B, Eid P Interleukin-15 plays a central role in human kidney physiology and cancer through the gamma c signaling pathway. PLoS ONE, 2012-02-21;7(2):e31624. 2012-02-21 [PMID: 22363690] (Neutralization, Human) Neutralization Human

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Bioinformatics

Gene Symbol IL2RG
Uniprot