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Common gamma Chain/IL-2 R gamma Antibody (633162) [Allophycocyanin]

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Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD3e PE-conjugated Monoclonal Antibody (Catalog # FAB100P) and either (A) Mouse Anti-Human Common gamma Chain/IL-2 R gamma APC-conjugated Monoclonal Antibody (Catalog # FAB2842A) or (B) Mouse IgG2BAllophycocyanin Isotype Control (Catalog # IC0041A). View our protocol for Staining Membrane-associated Proteins.
Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD3e PE-conjugated Monoclonal Antibody (Catalog # FAB100P) and either (A) Mouse Anti-Human Common gamma Chain/IL-2 R gamma APC-conjugated Monoclonal ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
633162
Clonality
Monoclonal
Host
Mouse
Conjugate
Allophycocyanin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB2842U-100UG
Alexa Fluor 405
FAB2842V-100UG
Alexa Fluor 488
FAB2842G-100UG
Alexa Fluor 532
FAB2842X
Alexa Fluor 594
FAB2842T-100UG
Alexa Fluor 647
FAB2842R-100UG
Alexa Fluor 700
FAB2842N-100UG
Alexa Fluor 750
FAB2842S-100UG
Allophycocyanin/Cy7
FAB2842APCCY7
Biotin
FAB2842B
DyLight 350
FAB2842D
DyLight 405
FAB2842E
DyLight 488
FAB2842K
DyLight 550
FAB2842L
DyLight 594
FAB2842M
DyLight 650
FAB2842W
DyLight 680
FAB2842Y
DyLight 755
FAB2842Z
HRP
FAB2842H
Janelia Fluor 549
FAB2842I
Janelia Fluor 646
FAB2842J
PE/Atto594
FAB2842PEATT594
PE/Cy5.5
FAB2842PECY55
PE/Cy7
FAB2842PECY7
PerCP
FAB2842C
Unconjugated
MAB2842
mFluor Violet 450 SE
FAB2842MFV450
mFluor Violet 500 SE
FAB2842MFV500
mFluor Violet 610 SE
FAB2842MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB2842
Carrier Free
MAB2842
Carrier Free
MAB2842-SP
Carrier Free
FAB2842V-100UG
Carrier Free
FAB2842U-100UG
Carrier Free
FAB2842T-100UG
Carrier Free
FAB2842S-100UG
Carrier Free
FAB2842R-100UG
Carrier Free
FAB2842N-100UG
Carrier Free
FAB2842G-100UG
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Common gamma Chain/IL-2 R gamma Antibody (633162) [Allophycocyanin] Summary

Specificity
Detects human Common gamma Chain/IL-2 R gamma in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R alpha , rhIL-2 R beta , rhIL-15 R alpha , recombinant mouse IL-2 R gamma , or recombinant canine IL-2 R alpha is observed. In Western blots, approximately 80% cross-reactivity with rhIL-2 R beta , 50% cross-reactivity with rhIL-15 R alpha and recombinant mouse IL-2 R alpha , and no cross-reactivity with
rhIL-2 R alpha is observed.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
IL2RG
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publication using
FAB2842A in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Common gamma Chain/IL-2 R gamma Antibody (633162) [Allophycocyanin]

  • CD132 antigen
  • CD132
  • CIDX
  • combined immunodeficiency, X-linked
  • common cytokine receptor gamma chain
  • Common gamma Chain
  • common gamma-chain
  • cytokine receptor common subunit gamma
  • gamma(c)
  • IL-2 R gamma
  • IL-2 receptor subunit gamma
  • IL2R gamma
  • IL-2R subunit gamma
  • IL2RG
  • IL-2RG
  • IMD4
  • interleukin 2 receptor, gamma
  • Interleukin-2 receptor subunit gamma
  • P64
  • SCIDX
  • SCIDX1
  • severe combined immunodeficiency

Background

The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid protein consisting of a 22 aa signal sequence, a 232 aa extracellular domain, a 29 aa transmembrane domain and an 86 aa cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL‑2 with any appreciable affinity, it is required for IL-2 receptor signaling. Besides IL-2, the gamma  chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15. IL-2 R gamma has been designated the common gamma chain ( gamma c). The site of molecular defects in X-linked SCID (severe combined immunodeficiency) has been mapped to the IL-2 R gamma gene.

  1. Minami, Y. et al. (1993) Annu. Rev. Immunol. 11:245.
  2. Noguchi, M. et al. (1993) Science 262:1877.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Common gamma Chain/IL-2 R gamma Antibody (FAB2842A)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.


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Bioinformatics

Gene Symbol IL2RG
Uniprot