Collagen VII Antibody (LH7.2) [DyLight 755]

Recombinant full-length human Collagen VII protein (Uniprot: Q02388)

Secreted. Extracellular matrix. Basement Membrane.

Recognizes an epitope located on collagenase digested Type VII collagen (150kDa), i.e. the non-helical carboxyl terminal region of the dimer. Binding is localized at the inferior border of the lamina densa as demonstrated by immunoelectron microscopy. Type VII is also found in the retina, where its function is unknown. It interacts with Laminin 5 and Fibronectin. Collagen VII is a stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.

IgG1 Kappa

Monoclonal

Mouse

COL7A1

Protein A or G purified

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Optimal dilution of this antibody should be experimentally determined.