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Claudin-11 Antibody (SR1352)

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Western Blot: Claudin-11 Antibody (SR1352) [NBP3-21885] - Western blot analysis using NBP3-21885 in SH-SY5Y cell lysate.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Flow
Clone
SR1352
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Claudin-11 Antibody (SR1352) Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
A synthesized peptide derived from human Claudin-11 (Uniprot #: O75508)
Specificity
Detects endogenous levels of total Claudin-11
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
CLDN11
Purity
Affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:100
  • Western Blot 1:500-1:2000
Theoretical MW
22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.4, 150mM NaCl, 50% glycerol.
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for Claudin-11 Antibody (SR1352)

  • claudin 11
  • Claudin11
  • Claudin-11
  • CLDN11
  • Oligodendrocyte-specific protein
  • OSP
  • OSPOTMoligodendrocyte transmembrane protein
  • OTM

Background

Oligodendrocyte specific protein belongs is a major component of central nervous system myelin that is necessary for normal CNS function. The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, and are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that the Claudin 11 protein determines the permeability between layers of myelin sheaths via focal adhesion and with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CLDN11