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CHREBP Antibody [PE]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ChIP, GS, ICC/IF, IHC, IP, PAGE, WB, ChIP, KO
Clonality
Polyclonal
Host
Rabbit
Conjugate
PE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB400-135AF350
Alexa Fluor 405
NB400-135AF405
Alexa Fluor 488
NB400-135AF488
Alexa Fluor 532
NB400-135AF532
Alexa Fluor 594
NB400-135AF594
Alexa Fluor 647
NB400-135AF647
Alexa Fluor 700
NB400-135AF700
Alexa Fluor 750
NB400-135AF750
Allophycocyanin
NB400-135APC
Biotin
NB400-135B
CoraFluor 1
NB400-135CL1
DyLight 350
NB400-135UV
DyLight 405
NB400-135V
DyLight 488
NB400-135G
DyLight 550
NB400-135R
DyLight 594
NB400-135DL594
DyLight 650
NB400-135C
DyLight 680
NB400-135FR
DyLight 755
NB400-135IR
FITC
NB400-135F
HRP
NB400-135H
Janelia Fluor 525
NB400-135JF525
Janelia Fluor 549
NB400-135JF549
Janelia Fluor 635
NB400-135JF635
Janelia Fluor 646
NB400-135JF646
Janelia Fluor 669
NB400-135JF669
PerCP
NB400-135PCP
Unconjugated
NB400-135
mFluor Violet 450 SE
NB400-135MFV450
mFluor Violet 500 SE
NB400-135MFV500
mFluor Violet 610 SE
NB400-135MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB400-135
BSA Free
NB400-135SS
BSA Free
NB400-135
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CHREBP Antibody [PE] Summary

Immunogen
A C-terminal synthetic peptide made to the human CHREBP protein sequence (between residues 800-852). [UniProt# Q9NP71, Isoform 1/Alpha]
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MLXIPL
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Chromatin Immunoprecipitation (ChIP)
  • Chromatin Immunoprecipitation
  • Gel Super Shift Assays
  • Immunoblotting
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Knockout Validated
  • SDS-Page
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Use in Mouse reported in scientific literature (PMID: 33812059).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for CHREBP Antibody [PE]

  • BHLHD14
  • CHREBPcarbohydrate-responsive element-binding protein
  • Class D basic helix-loop-helix protein 14
  • MIOWS basic-helix-loop-helix leucine zipper protein
  • MLX interacting protein-like
  • MLX interactor
  • MLX-interacting protein-like
  • MONDOBWilliams-Beuren syndrome chromosomal region 14 protein
  • WBSCR14Williams-Beuren syndrome chromosome region 14 protein 1
  • Williams Beuren syndrome chromosome region 14
  • Williams-Beuren syndrome chromosome region 14 protein 2
  • WS-bHLHbHLHd14carbohydrate response element binding protein

Background

ChREBP is a transcription factor involved in activating genes that encode enzymes of fatty acid biosynthesis in liver and adipose. The ChREBP protein binds and activates the carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. ChREBP may also play roles in lipid metabolism, obesity, and type II diabetes.

The CHREBP protein is missing in the multisystem developmental disorder, Williams-Beuren syndrome. CHREBP antibodies are useful tools for studying lipid and fatty acid metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CHREBP Antibody
[PE]
NB400-135PE
CHREBP Antibody [PE]
Species: Hu, Mu, Rt
Applications: WB, ChIP, GS, ICC/IF, IHC, IP, PAGE, WB, ChIP, KO

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ChIP Video Protocol
ChIP Webinar
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on CHREBP.

Check out the latest blog posts on CHREBP.
Deficiency of GluT1 leads to neurological problems while excess is involved in cancers
By Jamshed Arslan, Pharm. D., PhD. What Are GluTs?Mammalian cell metabolism is incomplete without glucose   . Glucose is a monosaccharide that is transported to the cells through facilitative diffusion, a ...  Read full blog post.
Insulin signaling in adipocytes: Carbohydrate-signaling transcription factor ChREBP is the link between lipolytic enzyme Hormone-Sensitive Lipase and lipogenic enzyme ELOVL6
By Jamshed Arslan, Pharm. D., PhD. Insulin resistance in adipocytes is a major feature of metabolic syndrome   . Disrupted adipose tissue metabolism can lead to accumulation of lipid intermediates in insul...  Read full blog post.
ChREBP, a glucose sensitive transcription factor with role in glucose-lipids homeostasis and cancer
ChREBP (carbohydrate response element-binding protein) is a glucose responsive basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that binds MLX and then carbohydrate response element /ChoRE for the induction of genes involved in ...  Read full blog post.
ChREBP and Fatty Acid Biosynthesis Regulation
Carbohydrate response element binding protein (ChREBP) is a transcription factor involved in activating genes that encode enzymes of fatty acid biosynthesis in liver and adipose. It is believed to be a key controller of hepatic lipogenesis and has a p...  Read full blog post.
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Bioinformatics

Gene Symbol MLXIPL