ChemR23/CMKLR1 Antibody (84939) [Allophycocyanin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ChemR23, also known as CMKLR1, is a 47-48 kDa 7-transmembrane member of the rhodopsin, or G-protein coupled receptor family 1. It has restricted expression on select cell types that, in primate, include adipocytes, astrocytes, endothelial cells, microglia/macrophages, chondrocytes, monocytes, osteocytes, NK cells, and plasmacytoid plus myeloid dendritic cells. In mouse, would studies show ChemR23 to be expressed by neutrophils and keratinocytes. The universally-agreed on ligand for ChemR23 is Chemerin, a 137 amino acid (aa) non-chemokine product of fibroblasts, platelets, adipocytes and endothelium. The Chermerin:ChemR23 system is suggested to promote chemotaxis for all ChemR23+ cells, and to induce angiogenesis via endothelial cell migration and MMP-2 and -9 activation. There is one alternative splice form that shows a deletion of aa 1 and 2 (NP_004063). Over the extracellular domains of ChemR23, human and mouse share 69% aa sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 3 of 3.

Publications using FAB362A	Applications	Species
Klatte-Schulz, F;Bormann, N;Bonell, A;Al-Michref, J;Nguyen, HL;Klöckner, P;Thiele, K;Moroder, P;Seifert, M;Sawitzki, B;Wildemann, B;Duda, GN; Pro-Resolving Mediators in Rotator Cuff Disease: How Is the Bursa Involved? Cells 2023-12-20 [PMID: 38201221] (Flow Cytometry, Human)	Flow Cytometry	Human
Paola Vinci Mesenchymal stromal cell-secreted chemerin is a novel immunomodulatory molecule driving the migration of ChemR23-expressing cells Cytotherapy, 2016-12-06;0(0):. 2016-12-06 [PMID: 27939374] (Flow Cytometry, Human)	Flow Cytometry	Human
Herova M, Schmid M, Gemperle C, Hersberger M ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. J Immunol, 2015-01-30;194(5):2330-7. 2015-01-30 [PMID: 25637017] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB362A

• ChemR23/CMKLR1 Antibodies
• ChemR23/CMKLR1 Protein