Immunohistochemistry: CEACAM-6/CD66c Antibody (1H7-4B) [NBP2-54626] - Analysis in human lung: Using Anti-CEACAM6 [1H7-4B] (10 ug/ml) developed with DAB-staining procedure. Dark line indicated shows CEACAM6 expression.
Flow Cytometry: CEACAM-6/CD66c Antibody (1H7-4B) [NBP2-54626] - Binding of 10 ug/ml primary positive control mAb (upper panel), Anti-CEACAM6 [1H7-4B] (lower panel), negative isotype matched control mAb (thin line) on ...read more
ELISA: CEACAM-6/CD66c Antibody (1H7-4B) [NBP2-54626] - Solid phase was coated with 3 ug/ml Anti-CEA binding human CEACAM1-CEACAM8. After washing, blocking and coating human CEACAM1 antigen, detecting antibody ...read more
Immunoprecipitation: CEACAM-6/CD66c Antibody (1H7-4B) [NBP2-54626] - Human granulocyte lysate: Utilizing 10 ug/ml Anti-CEACAM6 [1H7-4B]. Detection of the sample using 5 ug/ml pAb Anti-CEA followed by HRP-coupled ...read more
Western Blot: CEACAM-6/CD66c Antibody (1H7-4B) [NBP2-54626] - Detection using 10 μg/ml NBP2-54626 followed by HRP-coupled secondary antibody. Visualized by Chemiluminescence detection.
90 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. CEACAM 6 expression is strongly up-regulated already during early stages of adenocarcinoma formation e.g. in colon. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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