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CDC2/CDK1 Products

CDC2/CDK1 Antibody
CDC2/CDK1 Antibody
NBP1-85729
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Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
CDC2/CDK1 Antibody (2G9) - BS ...
CDC2/CDK1 Antibody (2G9) - BSA Free
NBP2-37626
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Species: Hu, Mu, Rt, Pm, Pm
Applications: WB, ELISA, ICC/IF, IHC
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
CDC2/CDK1 [p Tyr15] Antibody
CDC2/CDK1 [p Tyr15] Antibody
NB500-142
Species: Hu, Mu, Rt, Xp, Ze
Applications: WB
Host: Rabbit Polyclonal

Description

The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Human
Human
Human
Human
Human
Rat
Product By Gene ID 983
Alternate Names
  • CDC28A
  • CDC2MGC111195
  • cell cycle controller CDC2
  • Cell division control protein 2 homolog
  • Cell division protein kinase 1
  • cyclin-dependent kinase 1
  • DKFZp686L20222
  • EC 2.7.11.22
  • EC 2.7.11.23
  • G1 to S and G2 to M
  • p34 protein kinase
  • P34CDC2

Research Areas for CDC2/CDK1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Core ESC-Like Genes
Mitotic Regulators
Phospho-Specific
Stem Cell Markers