Human CD30/TNFRSF8 ELISA Kit (Colorimetric)

Characterization of the CD30 antigen has shown it to be in its mature form a transmembrane protein of about 120kDa elaborated from an 84kD cytoplasmic precursor primarily through glycosylation. The CD30 ligand (CD30L) has been identified, showing significant homology to TNF-alpha, TNF-beta, FasL, CD40L, CD27L and 4-1BBl. CD30L is expressed on activated T-cells. Interactions of the cytokine receptor CD30 with its ligand induces pleiotropic biologic effects, such as differentiation, activation, proliferation and cell death. CD30 expression is strictly dependent on activation and proliferation of T- and B-cells. In pathological conditions, CD30 positivity is regarded as a peculiar attribute of Hodgkin's and Reed-Sternberg cells. An 85kDa soluble form of the CD30 molecule (sCD30) has been shown to be released by CD30+ cell in vitro and in vivo. Increased serum levels of sCD30 have been reported for patients with CD30+ ALCL and CD30+ embryonal carcinoma of the testis and were found to correlate with the clinical phase of the disease, i.e. presentation complete remission (CR), relapse.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Array NBP1-91185

• CD30/TNFRSF8 Antibodies
• CD30/TNFRSF8 Antibody Pair
• CD30/TNFRSF8 ELISA Kits
• CD30/TNFRSF8 Lysate
• CD30/TNFRSF8 Proteins
• CD30/TNFRSF8 Proteins and Enzymes
• CD30/TNFRSF8 ELISAs