CD11c Antibody (ITGAX/1243) [DyLight 405]

Recombinant fragment (aa 637-827) of human CD11c protein (exact sequence is proprietary) (Uniprot: P20702)

Cell surface

Dendritic Cell Marker

Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.

IgG2b Kappa

Monoclonal

Mouse

ITGAX

Protein A or G purified

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Optimal dilution of this antibody should be experimentally determined.