CaM Kinase II alpha [p Thr286] Antibody

CaM KII is an important member of calcium/calmodulin-activated kinase, functioning in neural synaptic stimulation and T-cell receptor signaling. CaM KII has catalytic and regulatory domains. The binding of Ca++/calmodulin to its regulatory domain releases its autoinhibitory effect and activates the kinase. The activated CaM KII further autophosphorylates itself at Thr286 to render the kinase constitutively active. The threonine phosphorylation state of CaM KII can be regulated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaM KII at Thr286. On the other hand, PKA (protein kinase A) prevents this phosphorylation process through its inhibitory effect on PP1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.

Showing Publications 1 - 10 of 10.

Publications using NB300-184	Applications	Species
Mustafa Yalcinkaya, Wenli Liu, Tong Xiao, Sandra Abramowicz, Ranran Wang, Nan Wang, Marit Westerterp, Alan R. Tall Cholesterol trafficking to the ER leads to the activation of CaMKII/JNK/NLRP3 and promotes atherosclerosis Journal of Lipid Research 2024-03-22 [PMID: 38522750]
Iqtadar S, Khan A, Mumtaz SU et al. Vitamin D Deficiency (VDD) and Susceptibility towards Severe Dengue Fever—A Prospective Cross-Sectional Study of Hospitalized Dengue Fever Patients from Lahore, Pakistan Tropical Medicine and Infectious Disease 2023-01-05 [PMID: 36668950]
Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg, Bahar Najafi, Surui Wang, Anna-Luisa Warnke, Susanne Seitz, Daniela Hass, Sofiya Gancheva, Sabine Kahl, Bin Yang, Brian Finan, Kathrin Schwarz, Juergen G Okun, Michael Roden, Matthias Blüher, Timo D Müller, Natalie Krahmer, Christian Behrends, Oliver Plettenburg, Marta Miaczynska, Stephan Herzig, Anja Zeigerer Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes. Cell metabolism 2022-11-07 [PMID: 36243006]
Qiao Y, Li S, Liu W et al. Recent Advances of Rare-Earth Ion Doped Luminescent Nanomaterials in Perovskite Solar Cells Nanomaterials 2018-01-15 [PMID: 29342950]
Doran AC, Ozcan L, Cai B et al. CAMKIIg suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis. J. Clin. Invest. 2017-11-01 [PMID: 28972541] (IHC-P, Human)	IHC-P	Human
Meng FJ, Guo J, Zhang QG, Song B, Zhang GY. Autophosphorylated calcium/calmodulin-dependent protein kinase IIa (CaMKIIa) reversibly targets to and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in cerebral ischemia and reperfusion in hippocampus of rats. Brain Res 967:161-169. 2003-01-01 [PMID: 12650977]
Gleason MR, Higashijima S, Dallman J et al. (2003) Translocation of CaM kinase II to synaptic sites in vivo. Nature Neurosci 6:217-218. [PMID: 12563265]
Elgersma Y, Fedorov NB, Ikonen S et al. (2002) Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron 36:493-505. [PMID: 12408851]
Hudmon A, Schulman H. (2002) Neuronal Ca2+/calmodulin-dependent protein kinase II: The role of structure and autoregulation in cellular function. Annu Rev Biochem 71:473-510. [PMID: 12045104]
Kennedy MB. (1998) Signal transduction molecules at the glutamatergic postsynaptic membrane. Brain Res Rev 26:243-257. [PMID: 9651538]

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Human	06/13/2017	View Summary Application Western Blot Sample Tested human macrophage Species Human Lot ks715p
	5 reviewed by: Verified Customer	ICC	Mouse	06/13/2017	View Summary Application Immunocytochemistry Sample Tested Aorta tissue Species Mouse Lot ks715p
	5 reviewed by: Bishuang Cai	Flow	Mouse	06/13/2017	View Summary Application Flow Cytometry Sample Tested Peritoneal macrophages Species Mouse Lot ks715p
	5 reviewed by: Bishuang Cai	WB	Mouse	06/13/2017	View Summary Application Western Blot Sample Tested Bone Marrrow Derived Macrophages Species Mouse Lot ks715p
	5 reviewed by: Bishuang Cai	Flow	Human	05/24/2017	View Summary Application Flow Cytometry Sample Tested human macrophage Species Human Lot ks715p
	5 reviewed by: Bishuang Cai	WB	Human and Mouse	05/02/2017	View Summary Application Western Blot Sample Tested Bone Marrrow Derived Macrophages,human macrophage Species Human and Mouse Lot ks715p
	5 reviewed by: Verified Customer	WB	Human and Mouse	04/17/2017	View Summary Application Western Blot Sample Tested human macrophage,Mouse macrophages Species Human and Mouse Lot ks715p

Array NB300-184

• CaM Kinase II alpha Antibodies
• CaM Kinase II alpha ELISA Kits
• CaM Kinase II alpha Lysate
• CaM Kinase II alpha Proteins