CaM Kinase II alpha Products

Description

Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2).

Bioinformatics

Entrez	12322 Mouse 25400 Rat 815 Human
Uniprot	AAH40457 Human AAH40457.1 Human NM_171825 Human NP_057065.2 Human P11275 Rat Q9UQM7 Human
Product By Gene ID	815
Alternate Names	calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha calcium/calmodulin-dependent protein kinase II alpha calcium/calmodulin-dependent protein kinase II alpha-B subunit CaM kinase II alpha subunit CaM kinase II subunit alpha CAMKAcalcium/calmodulin-dependent protein kinase type II subunit alpha CaMK-II alpha subunit CaMK-II subunit alpha CaMKIINalpha CaM-kinase II alpha chain EC 2.7.11 EC 2.7.11.17 KIAA0968calcium/calmodulin-dependent protein kinase type II alpha chain

Research Areas for CaM Kinase II alpha

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Neurotransmission
Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases
Wnt Signaling Pathway