Calnexin Antibody (AF18) - BSA Free

Calnexin, also referred to as IP90, p88 and p90, is an ~90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatability complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase. (See catalog #

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Monkey.

We have publications tested in 4 applications: Block/Neutralize, ICC/IF, Immunocytochemistry/ Immunofluorescence, WB.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using NB300-518	Applications	Species
Christine Marques, Aaron Held, Katherine Dorfman, Joon Sung, Catherine Song, Amey S. Kavuturu, Corey Aguilar, Tommaso Russo, Derek H. Oakley, Mark W. Albers, Bradley T. Hyman, Leonard Petrucelli, Clotilde Lagier-Tourenne, Brian J. Wainger Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia Acta Neuropathologica 2024-03-13 [PMID: 38478117]
Gurri S, Siegenthaler B, Cangkrama M et al. NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5 EMBO molecular medicine 2023-10-09 [PMID: 37807968]
Launay N, Ruiz M, Planas-Serra L et al. RINT1 deficiency disrupts lipid metabolism and underlies a complex hereditary spastic paraplegia The Journal of clinical investigation 2023-07-17 [PMID: 37463447] (ICC/IF, Human)	ICC/IF	Human
Ma X, Li M, Liu Y et al. ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis Journal of molecular cell biology 2023-06-28 [PMID: 37381178] (ICC/IF, Human)	ICC/IF	Human
LM Daian, G Tanko, AM Vacaru, L Ghila, S Chera, AM Vacaru Modulation of Unfolded Protein Response Restores Survival and Function of beta-Cells Exposed to the Endocrine Disruptor Bisphenol A International Journal of Molecular Sciences, 2023-01-19;24(3):. 2023-01-19 [PMID: 36768343]
Cangkrama M, Liu H, Whipman J et al. A pro-tumorigenic mDia2-MIRO1 axis controls mitochondrial positioning and function in cancer-associated fibroblasts Cancer research 2022-08-23 [PMID: 35997559] (WB) Details: WB Dilutions: 1:500	WB
Ramadan AA, Mayilsamy K, McGill AR et al. Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity Viruses 2022-03-04 [PMID: 35336938] (Block/Neutralize)	Block/Neutralize
Schumann T, K�nig J, von Loeffelholz C et al. Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance Communications Biology 2021-07-01 [PMID: 34211098] (Immunocytochemistry/ Immunofluorescence)	Immunocytochemistry/ Immunofluorescence
Ullah HMA, Elfadl AK, Park S et al. Nogo-A Is Critical for Pro-Inflammatory Gene Regulation in Myocytes and Macrophages Cells 2021-01-31 [PMID: 33572505] (ICC/IF, Mouse)	ICC/IF	Mouse
Heider M, Eichner R, Stroh J et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma Molecular cell 2021-02-03 [PMID: 33571422]
Zhang X, Zhang J, Sun H et al. Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis Cell Mol Gastroenterol Hepatol 2019-03-01 [PMID: 30831319] (WB, Monkey)	WB	Monkey
Godbole A, Lyga S, Lohse MJ, Calebiro D. Internalized TSH receptors en route to the TGN induce local G s-protein signaling and gene transcription Nature Communications 2017-01-01 [PMID: 28874659] (ICC/IF, Mouse)	ICC/IF	Mouse
Hescot S, Amazit L, Lhomme M et al. Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches Oncotarget 2017-07-04 [PMID: 28698403] (ICC/IF, Human)	ICC/IF	Human
Galvin K et al. The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. Proc Natl Acad Sci U S A 89:8452-6. 1992-01-01 [PMID: 1326756]
Show All 14 Publications. Collapse Publications.

Array NB300-518

• Calnexin Antibodies
• Calnexin ELISA Kits
• Calnexin Lysates
• Calnexin Proteins