Western Blot: Calcium-sensing R/CaSR Antibody [NBP2-41271] - Western blot analysis of CASR in EL4 cell lysate with CASR antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry/ Immunofluorescence: Calcium-sensing R/CaSR Antibody [NBP2-41271] - Immunofluorescence of Calcium-sensing R/CASR in human kidney tissue with Calcium-sensing R/CASR antibody at 20 ug/mL.
Immunohistochemistry: Calcium-sensing R/CaSR Antibody [NBP2-41271] - Immunohistochemistry of Calcium-sensing R/CASR in human kidney tissue with Calcium-sensing R/CASRantibody at 5 ug/mL.
Antibody was raised against a 15 amino acid peptide near the amino terminus of human CASR. The immunogen is located within the first 50 amino acids of CASR. Amino Acid Squence: TSAYGPDQRAQKKGD
Specificity
At least two isoforms of CASR are known to exist.
Predicted Species
Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CASR
Purity
Peptide affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.
115, 125 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using NBP2-41271 in the following applications:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified
Alternate Names for Calcium-sensing R/CaSR Antibody - BSA Free
calcium-sensing receptor
CAR
CaSR
EIG8
extracellular calcium-sensing receptor
FHH
FIH
GPRC2A
GPRC2AHHC
HHC1
hypocalciuric hypercalcemia 1
NSHPT
parathyroid Ca(2+)-sensing receptor 1
Parathyroid cell calcium-sensing receptor
PCaR1
PCAR1MGC138441
Background
Calcium-Sensing Receptor (CaSR) is a member of the G protein-coupled receptor family. CaSR is an integral membrane protein that senses changes in the extracellular concentration of calcium ions and controls the release of parathyroid hormone. The activity of the calcium-sensing receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Mutations that inactivate CaSR lead to familial hypocalciuric hypercalcemia, whereas mutations that activate CaSR cause autosomal dominant hypocalcemia. Calcium-Sensing Receptor antibodies are useful tools for parathyroid studies and research on cellular calcium homeostasis regulation.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for Calcium-sensing R/CaSR Antibody (NBP2-41271)(1)
We have publications tested in 1 confirmed species: Mouse.
We have publications tested in 1 application: IHC-FrFl.
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IHC-FrFl
(1)
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Mouse
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Showing Publication 1 - 1 of 1.
Publication using NBP2-41271
Applications
Species
Wang H, Lu Y Commonly Used Higher-Than Physiological Extracellular Calcium Concentrations Reduce Cellular Excitability of Mouse Mntb Neurons Available at SSRN 4509183 2023-07-25 (IHC-FrFl, Mouse)
IHC-FrFl
Mouse
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