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Calcium-sensing R/CaSR Antibody [DyLight 488]

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Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-41271AF350
Alexa Fluor 405
NBP2-41271AF405
Alexa Fluor 488
NBP2-41271AF488
Alexa Fluor 532
NBP2-41271AF532
Alexa Fluor 594
NBP2-41271AF594
Alexa Fluor 647
NBP2-41271AF647
Alexa Fluor 700
NBP2-41271AF700
Alexa Fluor 750
NBP2-41271AF750
Biotin
NBP2-41271B
DyLight 350
NBP2-41271UV
DyLight 405
NBP2-41271V
DyLight 550
NBP2-41271R
DyLight 594
NBP2-41271DL594
DyLight 650
NBP2-41271C
DyLight 680
NBP2-41271FR
DyLight 755
NBP2-41271IR
FITC
NBP2-41271F
HRP
NBP2-41271H
Janelia Fluor 549
NBP2-41271JF549
Janelia Fluor 646
NBP2-41271JF646
PerCP
NBP2-41271PCP
Unconjugated
NBP2-41271
mFluor Violet 450 SE
NBP2-41271MFV450
mFluor Violet 500 SE
NBP2-41271MFV500
mFluor Violet 610 SE
NBP2-41271MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-41271
BSA Free
NBP2-41271
BSA Free
NBP2-41271-0.025mg
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Calcium-sensing R/CaSR Antibody [DyLight 488] Summary

Immunogen
Antibody was raised against a 15 amino acid peptide near the amino terminus of human CASR. The immunogen is located within the first 50 amino acids of CASR. Amino Acid Squence: TSAYGPDQRAQKKGD
Specificity
At least two isoforms of CASR are known to exist.
Predicted Species
Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CASR
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Calcium-sensing R/CaSR Antibody [DyLight 488]

  • calcium-sensing receptor
  • CAR
  • CaSR
  • EIG8
  • extracellular calcium-sensing receptor
  • FHH
  • FIH
  • GPRC2A
  • GPRC2AHHC
  • HHC1
  • hypocalciuric hypercalcemia 1
  • NSHPT
  • parathyroid Ca(2+)-sensing receptor 1
  • Parathyroid cell calcium-sensing receptor
  • PCaR1
  • PCAR1MGC138441

Background

Calcium-Sensing Receptor (CaSR) is a member of the G protein-coupled receptor family. CaSR is an integral membrane protein that senses changes in the extracellular concentration of calcium ions and controls the release of parathyroid hormone. The activity of the calcium-sensing receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Mutations that inactivate CaSR lead to familial hypocalciuric hypercalcemia, whereas mutations that activate CaSR cause autosomal dominant hypocalcemia. Calcium-Sensing Receptor antibodies are useful tools for parathyroid studies and research on cellular calcium homeostasis regulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CASR