BRCA1 [p Ser1524] Antibody

BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full length natures identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-200	Applications	Species
Bunch H, Jeong J, Kang K Et al. BRCA1-BARD1 regulates transcription through modulating topoisomerase II beta Open biology 2021-10-01 [PMID: 34610268] (IP, Human)	IP	Human
Jackson LJ, Pheneger JA, Pheneger TJ et al. The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease. Cell Immunol 2012-01-01 [PMID: 22078270]
Rusin M, Zajkowicz A, Butkiewicz D. Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. Mech Ageing Dev 2009-08-01 [PMID: 19559722] (WB, Human)	WB	Human

Array NB100-200

• BRCA1 Antibodies
• BRCA1 Antibody Pack
• BRCA1 ELISA Kits
• BRCA1 Proteins