Biliverdin Reductase B/BLVRB Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Clearance of heme in mammals is a two-step process starting with conversion of heme to biliverdin by heme oxygenase, followed by reduction of biliverdin to bilirubin by bilivredin reductase. Biliverdin IX b reductase (BLVRB) converts the  beta  isomer of biliverdin IX to bilirubin IX b, which constitutes 87% of total bilirubin in fetal bile. Therefore BLVRB is especially important for fetal heme metabolism and clearance (1). BLVRB is a cytoplasmic enzyme expressed at high levels in erythrocytes and liver, but is present in other tissues (2). The enzyme is identical to flavin reductase, which is an oxidoreductase that catalyses the NADPH-dependent reduction for a variety of flavins, such as riboflavin, FAD or FMN and met‑hemoglobin (3, 4). BLVRB is structurally distinct from BLVRA. In contrast to BLVRA, which prefers the biliverdin alpha  isomer but could also use the  beta  isomer as substrate, BLVRB is specific for the beta  isomer (5, 6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 2 of 2.

Publications using AF6568	Applications	Species
Nesbitt NM, Malone LE, Liu Z et al. Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis Free radical biology & medicine 12/24/2020 [PMID: 33359909]
NM Nesbitt, X Zheng, Z Li, JA Manso, WY Yen, LE Malone, J Ripoll-Roz, PJB Pereira, TJ Mantle, J Wang, WF Bahou In silico and crystallographic studies identify key structural features of biliverdin IX? reductase inhibitors having nanomolar potency J. Biol. Chem., 2018-02-27;0(0):. 2018-02-27 [PMID: 29487133] (Western Blot, Human)	Western Blot	Human

Array AF6568

• Biliverdin Reductase B/BLVRB Antibodies
• Biliverdin Reductase B/BLVRB ELISA Kit
• Biliverdin Reductase B/BLVRB Lysate
• Biliverdin Reductase B/BLVRB Proteins
• Biliverdin Reductase B/BLVRB Proteins and Enzyme