BACE-1 Antibody (137626)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BACE-1 (beta‑site APP cleaving enzyme-1) is an aspartic protease and an integral membrane protein (1, 2). It is the major beta secretase, and together with the gamma secretase, is responsible for generating the amyloid beta peptide (A beta ) from the amyloid precursor protein (APP) (3, 4). Because A beta is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer's disease. High levels of BACE-1 activity are sufficient to elicit neurodegeneration and neurological decline in vivo, indicating that inhibiting BACE-1 may block not only A beta -dependent but also A beta -independent pathogenic mechanisms (5). In addition to APP, BACE-1 also cleaves APP-like proteins 1 and 2, the cell adhesion protein P-selectin glycoprotein ligand-1 and beta -galactoside alpha 2,6-sialyltransferase, implying that BACE-1 may have additional functions involving the ectodomain shedding of membrane proteins (6 - 8).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Immunoprecipitation, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using MAB9311	Applications	Species
Jhilik Dey, Akanksha Roberts, Subhasis Mahari, Sonu Gandhi, Prem Prakash Tripathi Electrochemical Detection of Alzheimer’s Disease Biomarker, beta -Secretase Enzyme (BACE1), With One-Step Synthesized Reduced Graphene Oxide Frontiers in Bioengineering and Biotechnology 3/24/2022 [PMID: 35402415]
H Hampel, S Lista, E Vanmechele, H Zetterberg, FS Giorgi, A Galgani, K Blennow, F Caraci, B Das, R Yan, A Vergallo, Alzheimer’ &beta-Secretase1 biological markers for Alzheimer's disease: state-of-art of validation and qualification Alzheimers Res Ther, 2020-10-16;12(1):130. 10/16/2020 [PMID: 33066807]
Lei Liu, Li Ding, Matteo Rovere, Michael S. Wolfe, Dennis J. Selkoe A cellular complex of BACE1 and gamma -secretase sequentially generates A beta from its full-length precursor Journal of Cell Biology 2/4/2019 [PMID: 30626721]
Daisuke Tanokashira, Kazumi Motoki, Seiji Minegishi, Ai Hosaka, Naomi Mamada, Akira Tamaoka et al. LRP1 Downregulates the Alzheimer’s beta -Secretase BACE1 by Modulating Its Intraneuronal Trafficking1,2,3 eNeuro 4/10/2015 [PMID: 26464978]
Kazumi Motoki, Hideaki Kume, Akiko Oda, Akira Tamaoka, Ai Hosaka, Fuyuki Kametani et al. Neuronal beta ‐amyloid generation is independent of lipid raft association of beta ‐secretase BACE1: analysis with a palmitoylation‐deficient mutant Brain and Behavior 5/1/2012 [PMID: 22741101]
Amanda Gonzales, Boris Decourt, Aaron Walker, Rachel Condjella, Hikmet Nural, Marwan N. Sabbagh Development of a specific ELISA to measure BACE1 levels in human tissues Journal of Neuroscience Methods 10/30/2011 [PMID: 21889954]
Costantini C, Ko MH, Jonas MC, Puglielli L A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1. Biochem. J., 2007-11-01;407(3):383-95. 2007-11-01 [PMID: 17425515] (Immunoprecipitation, Western Blot, Human)	Immunoprecipitation, Western Blot	Human

Array MAB9311

• BACE-1 Antibodies
• BACE-1 ELISA Kits
• BACE-1 Lysate
• BACE-1 Protein
• BACE-1 ELISA
• BACE-1 Proteins and Enzymes