BACE-1 Products

Description

BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide.

Bioinformatics

Entrez	23621 Human 23821 Mouse 29392 Rat
Uniprot	AAF04142 Human AAH65492 Human AF190725 Human NP_036236 Human NP_620428.1 Human P56817 Human P56817-2 Human P56817-3 Human P56817-4 Human P56818 Mouse
Product By Gene ID	23621
Alternate Names	APP beta-secretase ASP2 Aspartyl protease 2 BACEAsp 2 beta-secretase 1 precursor variant 1 beta-secretase 1 beta-site amyloid beta A4 precursor protein-cleaving enzyme Beta-site amyloid precursor protein cleaving enzyme 1 Beta-site APP cleaving enzyme 1 beta-site APP-cleaving enzyme 1 beta-site APP-cleaving enzyme EC 3.4.23 EC 3.4.23.46 FLJ90568 HSPC104 KIAA1149 memapsin-2 Memapsin-2 Membrane-associated aspartic protease 2 transmembrane aspartic proteinase Asp2

Research Areas for BACE-1

Find related products by research area and learn more about each of the different research areas below.

Neurodegeneration
Neuroscience
Phospho-Specific