B7-H6 Antibody (875001) [Allophycocyanin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

B7-H6 is a glycosylated member of the B7 family of immune co‑stimulatory proteins (1, 2). Mature human B7-H6 consists of a 238 amino acid (aa) extracellular domain (ECD) that contains one Ig-like V domain and one Ig-like C1 domain, a 21 aa transmembrane segment, and a 171 aa cytoplasmic domain that contains one ITIM, one SH2, and one SH3 motif (3). Both of the Ig-like domains carry N-linked glycosylation (4). Within the ECD, human B7-H6 shares 99%, 94%, and 87% aa sequence identity with chimpanzee, orangutan, and gibbon B7-H6, respectively, and 53% - 56% with bovine, canine, and equine B7-H6. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells (4, 5). It does not show binding to NKp44, NKp46, or NKG2D (3, 6). Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis (3). B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors (3, 7). The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30‑dependent cell lysis (7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: FACS, Flow Cytometry.

Showing Publications 1 - 8 of 8.

Publications using FAB7144A	Applications	Species
Lee, S;Chae, SJ;Jang, IH;Oh, SC;Kim, SM;Lee, SY;Kim, JH;Ko, J;Kim, HJ;Song, IC;Kim, JK;Kim, TD; B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies EBioMedicine 2024-11-22 [PMID: 39579618] (FACS, Human)	FACS	Human
Zhao, NQ;Pi, R;Nguyen, DN;Ranganath, T;Seiler, C;Holmes, S;Marson, A;Blish, CA; NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells bioRxiv : the preprint server for biology 2024-06-27 [PMID: 38979175] (Flow Cytometry, Human)	Flow Cytometry	Human
Fisher, JG;Doyle, ADP;Graham, LV;Sonar, S;Sale, B;Henderson, I;Del Rio, L;Johnson, PWM;Landesman, Y;Cragg, MS;Forconi, F;Walker, CJ;Khakoo, SI;Blunt, MD; XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression Leukemia 2023-08-01 [PMID: 37528310] (Flow Cytometry, Human)	Flow Cytometry	Human
Avishai Shemesh, Harry Pickering, Kole T. Roybal, Lewis L. Lanier Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion Journal of Experimental Medicine 8/1/2022 [PMID: 35758909]
S González-O, MC Tellez-Bañ, AS Méndez-Cle, A Bravo-Cuel, G Hernández, LA Palafox-Ma, J Haramati, EJ Pedraza-Br, K Sánchez-Re, PC Ortiz-Laza Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells Journal of Immunology Research, 2022-04-12;2022(0):1810804. 2022-04-12 [PMID: 35465350] (Flow Cytometry, Human)	Flow Cytometry	Human
Miriam Aarsund, Filip M. Segers, Yunjie Wu, Marit Inngjerdingen Comparison of characteristics and tumor targeting properties of extracellular vesicles derived from primary NK cells or NK-cell lines stimulated with IL-15 or IL-12/15/18 Cancer Immunology, Immunotherapy 9/1/2022 [PMID: 35119498]
DR Makanga, F Da Rin de, G David, C Willem, L Dubreuil, N Legrand, T Guillaume, P Peterlin, A Lebourgeoi, MC Béné, A Garnier, P Chevallier, K Gendzekhad, A Cesbron, K Gagne, B Clemenceau, C Retière Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia Cancers (Basel), 2020-07-16;12(7):. 2020-07-16 [PMID: 32708751] (Flow Cytometry, Human)	Flow Cytometry	Human
Frank Fasbender, Martin Obholzer, Sarah Metzler, Regina Stöber, Jan G. Hengstler, Carsten Watzl Enhanced activation of human NK cells by drug-exposed hepatocytes Archives of Toxicology 2/1/2020 [PMID: 32060585]

Array FAB7144A

• B7-H6 Antibodies
• B7-H6 ELISA
• B7-H6 Proteins and Enzymes