ATG9A Antibody - BSA Free

ATG9A (autophagy-related protein 9A) is the only transmembrane member identified among the classical ATG proteins family which are essential to autophagy. Yeast ATG9 protein localizes to the pre-autophagosomal structure (PAS) as well as cytoplasmic punctate structures, whereas, the mammalian ATG9A localizes to endocytic compartments, the trans-Golgi network and autophagic membranes. Moreover, ATG9 is recruited to the PAS in an ATG11-dependent manner under nutrient-rich conditions, whereas during starvation, recruitment of ATG9 depends on Atg17p. ATG9A does not steadily reside at one place in cells, but rather dynamically shuttles between a juxta-nuclear trans-Golgi network compartment and late endosomes under autophagic or starvation conditions. Moreover, ATG9A accumulation is upregulated upon starvation in autophagosomes and the starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. ATG9A interacts with SUPT20H and has been proposed to mediate membrane transport to generate autophagosomes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Alligator, Drosophila.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-Fr, IP, WB.

Showing Publications 1 - 10 of 32. Show All 32 Publications. Collapse Publications.

Publications using NB110-56893	Applications	Species
Haihua Guo, Manuel Rogg, Julia Keller, Ann-Kathrin Scherzinger, Julia Jäckel, Charlotte Meyer, Alena Sammarco, Martin Helmstädter, Oliver Gorka, Olaf Gro beta , Christoph Schell, Wibke Bechtel-Walz, Ana Cristina Simões E Silva ADP-Ribosylation Factor-Interacting Protein 2 Acts as a Novel Regulator of Mitophagy and Autophagy in Podocytes in Diabetic Nephropathy Antioxidants 2024-01-08 [PMID: 38247505]
Bi Y, Yang G, Guo Z et al. Chronic high?salt intake induces cardiomyocyte autophagic vacuolization during left ventricular maladaptive remodeling in spontaneously hypertensive rats Experimental and Therapeutic Medicine 2023-02-16 [PMID: 36911373]
Jeong S, Kim Y, Park S et al. Lactobacillus plantarum Metabolites Elicit Anticancer Effects by Inhibiting Autophagy-Related Responses Molecules (Basel, Switzerland) 2023-02-16 [PMID: 36838877] (WB, Human)	WB	Human
Izumi H, Li Y, Yasunami M et al. Asymmetric Pericentrosomal CD133 Endosomes Induce the Unequal Autophagic Activity During Cytokinesis in CD133-Positive Human Neuroblastoma Cells Stem cells (Dayton, Ohio) 2022-03-14 [PMID: 35284915]
Kim Y, Lee Y, Heo G et al. Modulation of Intestinal Epithelial Permeability via Protease-Activated Receptor-2-Induced Autophagy Cells 2022-03-03 [PMID: 35269499] (WB, Human)	WB	Human
Wang R, Miao G, Shen JL et al. ESCRT dysfunction compromises endoplasmic reticulum maturation and autophagosome biogenesis in Drosophila Current biology : CB 2022-02-01 [PMID: 35134326]
Sanjar Batirovich Madrakhimov, Jin Young Yang, Jin Ha Kim, Jung Woo Han, Tae Kwann Park mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy Cell Communication and Signaling : CCS 2021-02-26 [PMID: 33637094]
Gu Q, Jiao S, Duan K et al. The BAD-BAX-caspase-3 cascade modulates synaptic vesicle pools via autophagy The Journal of neuroscience : the official journal of the Society for Neuroscience 2020-12-10 [PMID: 33303681]
Yu YS, Shin HR, Kim D et al. Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy Nature communications 2020-12-08 [PMID: 33293536]
Trelford, C B & Di Guglielmo, G M. Assessing methods to quantitatively validate TGF beta -dependent autophagy. Biol Open 2020-11-23 [PMID: 33168592] (WB, Mouse)	WB	Mouse
A. Negrete-Hurtado, M. Overhoff, S. Bera, E. De Bruyckere, K. Schätzmüller, M. J. Kye, C. Qin, M. Lammers, V. Kondylis, I. Neundorf, N. L. Kononenko Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons Nature Communications 2020-03-24 [PMID: 32210230]
Hale A, Merchant M, White M Detection and analysis of autophagy in the American alligator (Alligator mississippiensis) J. Exp. Zool. B Mol. Dev. Evol. 2020-02-15 [PMID: 32061056] (WB, Alligator)	WB	Alligator
Yang JY, Madrakhimov SB, Ahn DH et al. mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV Cell Commun Signal. 2019-06-14 [PMID: 31200728] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Yefimova M G, Buschiazzo A et al. Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa. Asian J Androl 2019-04-24 [PMID: 31031333] (ICC/IF, Human)	ICC/IF	Human
Jia S, Wang Y, You Z et al. Mammalian Atg9 contributes to the post-Golgi transport of lysosomal hydrolases by interacting with adaptor protein-1 FEBS Lett. 2017-11-20 [PMID: 29156099] (ICC/IF, Human)	ICC/IF	Human
Ugun-Klusek A, Tatham MH, Elkharaz J et al. Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway Cell Death Dis 2017-01-05 [PMID: 28055010] (IF/IHC, Mouse)	IF/IHC	Mouse
Staudt C, Gilis F, Boonen M, Jadot M. Molecular determinants that mediate the sorting of human ATG9A from the endoplasmic reticulum. Biochim. Biophys. Acta 2016-06-15 [PMID: 27316455] (IP, Human)	IP	Human
Cheong JW, Kim Y, Eom JI et al. Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance. Mol Med Rep 2016-04-01 [PMID: 26935591] (WB)	WB
Bader CA, Shandala T, Ng YS et al. Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes. Biol Open 2015-09-09 [PMID: 26353861] (WB, IF/IHC, Drosophila)	WB, IF/IHC	Drosophila
Kaushik S, Cuervo AM Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis Nat Cell Biol. 2015-05-10 [PMID: 25961502] (ICC/IF, WB, Rat, Mouse)	ICC/IF, WB	Rat, Mouse
Mitter SK, Song C, Qi X et al. Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Autophagy 2014-01-01 [PMID: 25484094] (WB)	WB
Ge L, Zhang M, Schekman R. Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment. Elife. 2014-12-16 [PMID: 25432021] (WB, Mouse)	WB	Mouse
Juarez E, Carranza C, Hernandez-Sanchez F et al. Nucleotide-oligomerizing domain-1 (NOD1) receptor activation induces pro-inflammatory responses and autophagy in human alveolar macrophages. BMC Pulm Med. 2014-09-25 [PMID: 25253572] (WB, Human)	WB	Human
Bejarano E, Yuste A, Patel B et al. Connexins modulate autophagosome biogenesis. Nat. Cell Biol. 2014-04-06 [PMID: 24705551] (WB, ICC/IF, Rat)	WB, ICC/IF	Rat
Nah J, Pyo JO, Jung S et al. BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid beta 42. Autophagy 2013-12-01 [PMID: 24145555]
Zhang L, Zhang J, Shea K et al. Autophagy in Pancreatic Acinar Cells in Caerulein-treated Mice: Immunolocalization of Related Proteins and Their Potential as Markers of Pancreatitis. Toxicol Pathol 2013-05-02 [PMID: 23640381] (WB, Mouse)	WB	Mouse
Chen H, Luo Z, Dong L et al. CD133/Prominin-1-Mediated Autophagy and Glucose Uptake Beneficial for Hepatoma Cell Survival. PLoS One 2013-01-01 [PMID: 23437259] (WB, Human)	WB	Human
Curtis S, Jones CJ, Garrod A et al. Identification of Autophagic Vacuoles and Regulators of Autophagy in Villous Trophoblast from Normal Term Pregnancies and in Fetal Growth Restriction J Matern Fetal Neonatal Med 2012-10-08 [PMID: 23039021] (IF/IHC, Human)	IF/IHC	Human
Cant JS, Goodale MA. Scratching beneath the surface: new insights into the functional properties of the lateral occipital area and parahippocampal place area. J Neurosci 2011-06-01 [PMID: 21632946] (Human)		Human
Herd HL, Malugin A, Ghandehari H. Silica nanoconstruct cellular toleration threshold in vitro. J Control Release;153(1):40-8. 2011-07-15 [PMID: 21342660] (WB, Mouse, Human)	WB	Mouse, Human
Takahashi Y, Meyerkord CL, Hori T et al. Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy. Autophagy 2011-01-01 [PMID: 21068542]
Show All 32 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Human	09/08/2009	View Summary Application Western Blot Sample Tested Human brain extract, Sample Amount: 40 ug Species Human Lot SSB

Array NB110-56893

• ATG9A Antibodies
• ATG9A Lysates
• ATG9A Proteins