STING/TMEM173 Antibody (723505) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

STING (Stimulator of Interferon Genes), also called ERIS, MPYS, or MITA and designated TMEM173, is a 40-42 kDa 4-transmembrane protein that mediates both antiviral and MHC-II antigen recognition responses. STING is found predominantly in the endoplasmic reticulum. It acts as an adaptor protein for intracellular viral detection molecules, participating in the induction of type I interferon. It also may play a role in the initiation of apoptosis following MHC-II engagement. Cells known to express STING include B cells, dendritic cells, macrophages, and monocytes. Human STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). Ubiquitination occurs at Lys150, and phosphorylation occurs at Ser358. STING forms 80 kDa homodimers. There are two potential splice forms, one that shows a 25 aa substitution for aa 1-173, and another that possesses an alternative start site at Met215, coupled to a premature truncation following Arg334. Over aa 215-379, human and mouse STING share 76% aa sequence identity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ChIP, ICC, IHC, Western Blot.

Showing Publications 1 - 10 of 28. Show All 28 Publications. Collapse Publications.

Publications using MAB7169	Applications	Species
Jia, M;Chai, L;Wang, J;Wang, M;Qin, D;Song, H;Fu, Y;Zhao, C;Gao, C;Jia, J;Zhao, W; S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens Nature communications 2024-02-26 [PMID: 38409248] (ICC, Human, Mouse)	ICC	Human, Mouse
Hirschenberger, M;Lepelley, A;Rupp, U;Klute, S;Hunszinger, V;Koepke, L;Merold, V;Didry-Barca, B;Wondany, F;Bergner, T;Moreau, T;Rodero, MP;Rösler, R;Wiese, S;Volpi, S;Gattorno, M;Papa, R;Lynch, SA;Haug, MG;Houge, G;Wigby, KM;Sprague, J;Lenberg, J;Read, C;Walther, P;Michaelis, J;Kirchhoff, F;de Oliveira Mann, CC;Crow, YJ;Sparrer, KMJ; ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling Nature communications 2023-11-01 [PMID: 37914730] (Western Blot, Human)	Western Blot	Human
Zhang, H;Li, J;Yu, Y;Ren, J;Liu, Q;Bao, Z;Sun, S;Liu, X;Ma, S;Liu, Z;Yan, K;Wu, Z;Fan, Y;Sun, X;Zhang, Y;Ji, Q;Cheng, F;Wei, PH;Ma, X;Zhang, S;Xie, Z;Niu, Y;Wang, YJ;Han, JJ;Jiang, T;Zhao, G;Ji, W;Izpisua Belmonte, JC;Wang, S;Qu, J;Zhang, W;Liu, GH; Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging Cell reports 2023-05-31 [PMID: 37261950] (ICC, Human)	ICC	Human
Ferecsk�, AS;Smallwood, MJ;Moore, A;Liddle, C;Newcombe, J;Holley, J;Whatmore, J;Gutowski, NJ;Eggleton, P; STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases Biomedicines 2023-05-05 [PMID: 37239045] (IHC, Western Blot, Human)	IHC, Western Blot	Human
JH Lee, M Kwon, WY Lim, CR Yoo, Y Yoon, D Han, JH Ahn, K Yoon YAP inhibits HCMV replication by impairing STING-mediated nuclear transport of the viral genome PloS Pathogens, 2022-12-01;18(12):e1011007. 2022-12-01 [PMID: 36455047] (ICC, Western Blot, Human)	ICC, Western Blot	Human
M Pan, Y Yin, T Hu, X Wang, T Jia, J Sun, Q Wang, W Meng, J Zhu, C Dai, H Hu, C Wang UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation Autophagy, 2022-05-30;0(0):. 2022-05-30 [PMID: 35543189] (Western Blot, Human)	Western Blot	Human
Deater M, Tamhankar M, Lloyd RE. TDRD3 is an antiviral restriction factor that promotes IFN signaling with G3BP1 PLOS Pathogens 2022-01-27 [PMID: 35085371]
Deater M, Tamhankar M, Lloyd RE. TDRD3 is an antiviral restriction factor that promotes IFN signaling with G3BP1 PLOS Pathogens 1/27/2022 [PMID: 35085371]
Alice Lepelley, Erika Della Mina, Erika Van Nieuwenhove, Lise Waumans, Sylvie Fraitag, Gillian I. Rice et al. Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A Journal of Experimental Medicine 2021-10-04 [PMID: 34387651]
Bin Lin, Sofia Torreggiani, Dana Kahle, Dax G. Rumsey, Benjamin L. Wright, Marco A. Montes-Cano et al. Case Report: Novel SAVI-Causing Variants in STING1 Expand the Clinical Disease Spectrum and Suggest a Refined Model of STING Activation Frontiers in Immunology 3/22/2021 [PMID: 33833757]
S Segura-Bay, M Villamor-P, CS Attolini, LM Koenig, M Sanchiz-Ca, SJ Boulton, TH Stracker Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres Cell Rep, 2020-08-04;32(5):107983. 2020-08-04 [PMID: 32755577] (ChIP, ICC, Western Blot, Human)	ChIP, ICC, Western Blot	Human
Alice Lepelley, Maria José Martin-Niclós, Melvin Le Bihan, Joseph A. Marsh, Carolina Uggenti, Gillian I. Rice et al. Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling Journal of Experimental Medicine 2020-11-02 [PMID: 32725128]
Irene Lo Cigno, Federica Calati, Cinzia Borgogna, Alessandra Zevini, Silvia Albertini, Licia Martuscelli et al. Human Papillomavirus E7 Oncoprotein Subverts Host Innate Immunity via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor Genes Journal of Virology 2020-01-31 [PMID: 31776268]
William Riedl, Dhiraj Acharya, Jung-Hyun Lee, Guanqun Liu, Taryn Serman, Cindy Chiang et al. Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity Cell Host & Microbe 2019-10-09 [PMID: 31600501]
M Gentili, X Lahaye, F Nadalin, GFP Nader, E Puig Lomba, S Herve, NS De Silva, DC Rookhuizen, E Zueva, C Goudot, M Maurin, A Bochnakian, S Amigorena, M Piel, D Fachinetti, A Londoño-Va, N Manel The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus Cell Rep, 2019-02-26;26(9):2377-2393.e13. 2019-02-26 [PMID: 30811988] (Western Blot, Human)	Western Blot	Human
L Zhang, N Wei, Y Cui, Z Hong, X Liu, Q Wang, S Li, H Liu, H Yu, Y Cai, Q Wang, J Zhu, W Meng, Z Chen, C Wang The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway PLoS Pathog., 2018-11-02;14(11):e1007435. 2018-11-02 [PMID: 30388174] (ICC, Human)	ICC	Human
L Yang, L Wang, H Ketkar, J Ma, G Yang, S Cui, T Geng, DG Mordue, T Fujimoto, G Cheng, F You, R Lin, E Fikrig, P Wang UBXN3B positively regulates STING-mediated antiviral immune responses Nat Commun, 2018-06-13;9(1):2329. 2018-06-13 [PMID: 29899553] (ICC, Mouse)	ICC	Mouse
R Ghosh, S Roy, S Franco PARP1 depletion induces RIG-I-dependent signaling in human cancer cells PLoS ONE, 2018-03-28;13(3):e0194611. 2018-03-28 [PMID: 29590171] (Western Blot, Human)	Western Blot	Human
S Albertini, I Lo Cigno, F Calati, M De Andrea, C Borgogna, V Dell'Oste, S Landolfo, M Gariglio HPV18 Persistence Impairs Basal and DNA Ligand-Mediated IFN-? and IFN-?Production through Transcriptional Repression of Multiple Downstream Effectors of Pattern Recognition Receptor Signaling J. Immunol., 2018-01-31;0(0):. 2018-01-31 [PMID: 29386255] (Western Blot, Human)	Western Blot	Human
HJ Choi, A Park, S Kang, E Lee, TA Lee, EA Ra, J Lee, S Lee, B Park Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses Nat Commun, 2018-01-09;9(1):125. 2018-01-09 [PMID: 29317664] (Western Blot, Human)	Western Blot	Human
YA Chen, YL Shen, HY Hsia, YP Tiang, TL Sung, LY Chen Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway Nat. Struct. Mol. Biol., 2017-11-06;0(0):. 2017-11-06 [PMID: 29106411] (Western Blot, Human)	Western Blot	Human
T Deschamps, M Kalamvoki Evasion of the STING DNA sensing pathway by the VP11/12 of herpes simplex virus type 1 J. Virol., 2017-07-27;0(0):. 2017-07-27 [PMID: 28592536] (Western Blot, Human)	Western Blot	Human
J Gaston, L Cheradame, V Yvonnet, O Deas, MF Poupon, JG Judde, S Cairo, V Goffin Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents Oncotarget, 2016-11-22;7(47):77205-77224. 2016-11-22 [PMID: 27791205] (ICC, Human)	ICC	Human
Bernard Dib, Haijiang Lin, Daniel E. Maidana, Bo Tian, John B. Miller, Peggy Bouzika et al. Mitochondrial DNA has a pro-inflammatory role in AMD Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2015-11-01 [PMID: 26305120]
Hansen K, Prabakaran T, Laustsen A et al. Listeria monocytogenes induces IFN-beta expression through an IFI16-, cGAS- and STING-dependent pathway. EMBO J 8/1/2014 [PMID: 24970844]
Kalamvoki M, Roizman B HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation. Proc Natl Acad Sci U S A, 2014-01-21;111(5):E611-7. 2014-01-21 [PMID: 24449861] (Western Blot, Human)	Western Blot	Human
Berg R, Rahbek S, Kofod-Olsen E, Holm C, Melchjorsen J, Jensen D, Hansen A, Jorgensen L, Ostergaard L, Tolstrup M, Larsen C, Paludan S, Jakobsen M, Mogensen T T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication. PLoS ONE, 2014-01-03;9(1):e84513. 2014-01-03 [PMID: 24404168] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Schoggins J, MacDuff D, Imanaka N, Gainey M, Shrestha B, Eitson J, Mar K, Richardson R, Ratushny A, Litvak V, Dabelic R, Manicassamy B, Aitchison J, Aderem A, Elliott R, Garcia-Sastre A, Racaniello V, Snijder E, Yokoyama W, Diamond M, Virgin H, Rice C Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature, 2013-11-27;505(7485):691-5. 2013-11-27 [PMID: 24284630] (Western Blot, Human)	Western Blot	Human
Show All 28 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	WB	Human	10/11/2020	View Summary Application Western Blot Sample Tested HeLa cells,U2OS cells Species Human Lot CFWR0218031 Comments Comments Antibody used at 0.105ug/mL or 1/2000. Blocked and incubated with 5% milk in TBST overnight at 4C. Blot detected using PICO Plus chemiluminescence reagent (Life Technologies).

Array MAB7169

• STING/TMEM173 Antibodies
• STING/TMEM173 ELISA Kits
• STING/TMEM173 Lysate
• STING/TMEM173 Proteins