Apolipoprotein E R2/ApoE R2 Antibody - BSA Free

ApoER2 (apolipoprotein E receptor 2 or LDL receptor related protein 8) is a member of LDL receptor (LDLR) family and it acts as a cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. ApoER2 facilitates extracellular RELN signal transduction to intracellular signaling processes, mainly through binding with DAB1 on its cytoplasmic tail. RELN acts via both VLDLR and ApoER2 to regulate tyrosine phosphorylation mediated DAB1 activation and microtubule function in neuronal cells. ApoER2 possess higher affinity for RELN compared to VLDLR and is therefore, a key player in Reelin pathway that governs forebrain's neuronal layering during prenatal brain development. ApoER2 associates with ER resident receptor-associated protein (RAP) as well as with dimers of beta 2-glycoprotein I. In the vasculature, ApoER2 has been suggested to implicate in suppressing platelet aggregation. Moreover, ApoER2 is highly expressed in epididymis (initial segment), where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), which are required for sperm maturation. ApoER2 also function as an endocytic receptor and defective ApoER2 have been linked to myocardial infarction type 1 (MCI1).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ICC/IF, PAGE, WB.

Showing Publications 1 - 8 of 8.

Publications using NB100-2216	Applications	Species
Tatsuaki Daimon, Atrayee Bhattacharya, Keyi Wang, Naoki Haratake, Ayako Nakashoji, Hiroki Ozawa, Yoshihiro Morimoto, Nami Yamashita, Takeo Kosaka, Mototsugu Oya, Donald W. Kufe MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells Cell Death Discovery 2024-01-05 [PMID: 38182558]
Heo J, Kang H Platelet-derived growth factor-stimulated pulmonary artery smooth muscle cells regulate pulmonary artery endothelial cell dysfunction through extracellular vesicle miR-409-5p Biological chemistry 2023-10-31 [PMID: 37903646]
Li Q, Morrill NK, Moerman-Herzog AM et al. Central repeat fragment of reelin leads to active reelin intracellular signaling and rescues cognitive deficits in a mouse model of reelin deficiency Cellular signalling 2023-06-12 [PMID: 37315752] (WB, Human)	WB	Human
Fang Z, Zhong M, Zhou L et al. Low-density lipoprotein receptor-related protein 8 facilitates the proliferation and invasion of non-small cell lung cancer cells by regulating the Wnt/beta-catenin signaling pathway Bioengineered 2022-03-01 [PMID: 35246020] (WB, Human)	WB	Human
Arimitsu N, Taka, K, Fujiwara N, et al. Roles of Reelin/Disabled1 pathway on functional recovery of hemiplegic mice after neural cell transplantation; Reelin promotes migration toward motor cortex and maturation to motoneurons of neural grafts Exp. Neurol. 2019-06-08 [PMID: 31185198] (ICC/IF, Mouse)	ICC/IF	Mouse
Pillay S, Zou W, Cheng F et al. AAV serotypes have distinctive interactions with domains of the cellular receptor AAVR J. Virol. 2017-07-05 [PMID: 28679762] (WB, Human)	WB	Human
Wang W, Moerman-Herzog AM, Slaton A, Barger SW Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2. Neurobiol. Aging 2016-10-11 [PMID: 27810638] (WB, PAGE, Mouse)	WB, PAGE	Mouse
Ding J, Bowes R C. Synaptic Expression of Apoer2 in the Plexiform Layers of Mouse Retina. J Comp Neurol 2000-07-25 [PMID: 10906706]

Array NB100-2216

• Apolipoprotein E R2/ApoE R2 Antibodies
• Apolipoprotein E R2/ApoE R2 Lysate
• Apolipoprotein E R2/ApoE R2 Proteins
• Apolipoprotein E R2/ApoE R2 Proteins and Enzyme