Aly Antibody (11G5) - BSA Free

Pre-mRNA splicing plays an important role in regulation of gene expression. During the splicing process, specific proteins are recruited to the mRNA and assembled into a complex of mRNA-protein near the exon-exon junction. This complex is termed the mRNA-protein complex (mRNP) or the exon-exon junction complex. The proteins that are found in this complex include: Y14, magoh, Aly/REF, RNPS1, Upf3, and DEK.1-5 Aly (also known as mREF1-I) is the mammalian homologue of the yeast mRNA export factor Yra1p.6-7 It is a 233 amino acid RNAbinding protein that contains a RNA-binding domain and is recruited to the mRNP complexes during the splicing. Excess of recombinant expression of Aly in the cells increases both the rate and efficiency of spliced and unspliced mRNA export (in vivo) from the nucleus to the cytoplasm. In contrast to the Y14 protein, Aly is dissociated from the mRNAs after the export to the cytoplasm.1, 5-6

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 4 of 4.

Publications using NB100-670	Applications	Species
tapescu i, taschuk f, Whig K et al. The RNA Helicase DDX39A Binds a Conserved Structure in Chikungunya Virus RNA to Control Infection SSRN Electronic Journal 2022-11-09 [PMID: 37949067]
tapescu i, taschuk f, Whig K et al. The RNA Helicase DDX39A Binds a Conserved Structure in Chikungunya Virus RNA to Control Infection SSRN Electronic Journal 2022-11-09 [PMID: 37949067] (ICC/IF, Human)	ICC/IF	Human
Okada M, Jang S-W, Ye K. Akt phosphorylation nuclear phosphoinositide association mediate mRNA export cell proliferation activities by ALY. PNAS;105(25):8649-8654. 2008-01-01 [PMID: 18562279]
Majerciak, V, Yamanegi, K, Nie, S H, Zheng, Z-M. Structural Functional Analyses of Kaposi Sarcoma-associated Herpesvirus ORF57 Nuclear Localization Signals in Living Cells. ,281, 28365-28378. 2006-01-01 [PMID: 16829516]

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Masashi Okada	WB	Human	07/15/2023	View Summary Application Western Blot Sample Tested 293 cell extract,293T cell line Species Human Lot forgot

Array NB100-670

• Aly Antibodies
• Aly ELISA Kits
• Aly Proteins