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Activin RIB/ALK-4 Antibody (207304)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clone
207304
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price
Carrier Free
MAB1477-SP
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Activin RIB/ALK-4 Antibody (207304) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Activin RIB/ALK-4
Leu32-Glu126
Accession # NP_031421
Specificity
Detects mouse Activin RIB/ALK-4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, shows 100% cross-reactivity with recombinant human (rh) Activin RIB, 20% cross-reactivity with rhActivin RIA, and no cross-reactivity with rhActivin RIIA or rhActivin RIIB.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
ACVR1B
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Activin RIB/ALK-4 Antibody (207304)

  • activin A receptor, type IB
  • Activin receptor type IB
  • Activin receptor-like kinase 4
  • Activin RIB
  • ActivinRIB
  • ActRIB
  • ACVR1B
  • ACVRLK4ACTR-IB
  • ALK4
  • ALK-4
  • ALK4activin A receptor, type II-like kinase 4
  • EC 2.7.11
  • EC 2.7.11.30
  • Serine/threonine-protein kinase receptor R2
  • SKR2activin receptor type-1B

Background

Activin RIB, also known as ALK-4, is a glycosylated 58 kDa type I transmembrane receptor that belongs to the superfamily of TGF-beta serine/threonine kinase receptors. Activin RIB associates with Activin RIIB to form a receptor complex for activin and inhibin molecules (1). These ligands bind to Activin RIIB which then associates with, and phosphorylates, the cytoplasmic domain of Activin RIB to initiate signal transduction (2, 3). Mature mouse Activin RIB consists of a 103 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 356 aa cytoplasmic region that includes the kinase domain (4). Within the ECD, mouse Activin RIB shares 93% and 98% aa sequence identity with human and rat Activin RIB, respectively. It shares 23% - 38% aa sequence identity with other mouse type I receptors Activin RIA, BMPR-IA, BMPR-IB, and TGF-beta RI. Activin receptor signaling is modulated by the direct interaction of Activin RIB with cripto or inhibin binding protein (5 - 7). Activin RIB is excluded from the signaling complex if Activin RIIB first binds inhibin and betaglycan (8). Activin RIB functions in a wide variety of growth and differentiation processes, including embryonic cell fate and axis determination, cell proliferation, apoptosis, and tumorigenesis (1, 9, 10).

  1. Chen, Y.-G. et al. (2006) Exp. Biol. Med. 231:534.
  2. Attisano, L. et al. (1996) Mol. Cell. Biol. 16:1066.
  3. Tsuchida, K. et al. (1995) Endocrinology 136:5493.
  4. Ebner, R. et al. (1993) Science 260:1344.
  5. Chapman, S.C. and T.K. Woodruff (2001) Mol. Endocrinol. 15:668.
  6. Bianco, C. et al. (2002) Mol. Cell. Biol. 22:2586.
  7. Gray, P.C. et al. (2003) Proc. Natl. Acad. Sci. 100:5193.
  8. Lewis, K.A. et al. (2000) Nature 404:411.
  9. Gu, Z. et al. (1998) Genes Dev. 12:844.
  10. Chen, Y. et al. (2004) Dev. Biol. 268:280.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ACVR1B
Uniprot