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Response To Ischemia Pathway Bioinformatics

Ischemia is a condition in which patients do not receive enough blood flow to tissues either at a specific location or across the whole body. Some tissues are able to fully recover after an instance of ischemia, but others, such as brain tissue, can die off in as little as five minutes. The body has several responses to ischemia. In tissues where the injury is small, angiogenesis and the remodeling of blood vessels occurs to generate more blood vessels around the affected area. Reperfusion is also used to increase blood flow, but prolonged cases may be damaging to the heart. There are many responses that occur in the brain under ischemic conditions, such as a mass release of glutamate, which becomes toxic. There is also a large increase of dopamine which may cause striatal neuronal death. There are some neuroprotective transmitters released under ischemic conditions however, including GAGA, serotonin, and adenosine.

Top Research Reagents

We have 5799 products for the study of the Response To Ischemia Pathway that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

iNOS Antibody - BSA Free

NB300-605

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Flow, IB

3 Reviews

130 Publications

IL-6 [HRP]

D6050B

Species Human

776 Publications

eNOS Antibody - BSA Free

NB300-500

$Western Blot: eNOS Antibody - BSA Free [NB300-500] - Fractionated, compared to single exposure, radiation more profoundly suppressed TM and eNOS. Representative Western blot analysis and quantification of KLF2 (n = 5) and KLF4 (n = 3) levels in whole-cell lysates from nonirradiated (sham) and irradiated HUVECs 4 h and 24 h after exposure to either five fractions of 2 Gy (5 x 2 Gy) or single exposure to 10 Gy. Fractions delivered at 24-h intervals. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/32382091/) licensed under a CC-BY license.$

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-Fr

3 Reviews

28 Publications

Carbonic Anhydrase I/CA1 Antibody

NBP1-88191

$Western Blot: Carbonic Anhydrase I/CA1 Antibody [NBP1-88191] - Comparative proteome analysis of 3xTg-AD and control samples at different stages of AD. Immunoblot analysis of most regulated hits. Soluble fractions of brain proteins were analyzed from four 2-month-old control and 3xTg-AD mice animals, respectively. Hebp1 and Glo1 levels were consistently elevated in the transgenic animals as compared to wild type controls. Ca1 levels were reduced in transgenic animals. Image collected and cropped by CiteAb from the following publication (https://elifesciences.org/articles/47498), licensed under a CC-BY license.$