Pentraxin 3/TSG-14 Products

Description

Pentraxin 3 (PTX3) is the prototypic member of the long pentraxin family sharing the C-terminal domain with short pentraxins (C-reactive protein and serum amyloid P component) and containing a unique N-terminal domain. The protein is a soluble pattern recognition receptor and represents a nonredundant component of the humoral innate immunity against selected pathogens. PTX3 is rapidly produced and released at inflammatory sites by diverse cell types including monocytes/macrophages, endothelial cells, vascular smooth muscle cells, fibroblasts, and adipocytes. It interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens. PTX3 has been implicated in vascular damage, angiogenesis, atherosclerosis, and restenosis.

Bioinformatics

Uniprot	NP_002843 Human P26022 Human P48759 Mouse
Product By Gene ID	5806
Alternate Names	alpha-induced protein 5 pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor Pentaxin-related protein PTX3 pentraxin 3, long pentraxin-3 pentraxin-related gene, rapidly induced by IL-1 beta pentraxin-related protein PTX3 TNF alpha-induced protein 5 TNFAIP5 TSG14 TSG-14pentaxin-related gene, rapidly induced by IL-1 beta Tumor necrosis factor alpha-induced protein 5 tumor necrosis factor, alpha-induced protein 5 Tumor necrosis factor-inducible gene 14 protein tumor necrosis factor-inducible protein TSG-14