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Cancer Research

NPC1: A Potential Target For Triple-Negative Breast Cancer

By Natalia Gurule, PhD

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Triple-Negative Breast Cancer

Niemann-Pick C1

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Understanding ‘Y’ in Breast Cancer: Crucial Role of DNA/RNA-binding Protein YB-1 in the Development, Pre-Invasive, and Metastatic Phases

Jamshed Arslan, Pharm D, PhD

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Carbonic Anhydrase IX/CA9

Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness

Immunohistochemical staining of paraffin-embedded human breast carcinoma with rabbit polyclonal Oct4 antibody.

By Jamshed Arslan, Pharm D, PhD

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HIF-2 alpha/EPAS1

Deficiency of GluT1 leads to neurological problems while excess is involved in cancers

Immunohistochemical staining of formalin fixed paraffin embedded tissue of human placenta with rabbit polyclonal Glut1 antibody and staining developed using HRP-DAB with hematoxylin counterstaining.

By Jamshed Arslan, Pharm. D., PhD.

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GluT1-deficiency syndrome (GDS)

Hepatocellular Carcinoma

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Detecting HIF alpha and beyond: Best controls for hypoxia Western blot analysis

Analysis of HIF-1 alpha expression in whole cell lysates from HeLa cells in culture treated or untreated with cobalt chloride and independent antibody validation where two different antibodies to HIF-1 alpha were used for immunoprecipitation and detection.

By Rosa Moreno, PhD.

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Suppressing breast cancer metastasis: The role of hypoxia-induced RhoB expression and activation

Expression of RhoA, B and C detected in the cytoplasm of A431 cells, a model of human epidermoid carcinoma, compared to negative control analyzed in the absence of RhoA Antibody (1A11-4G10) [NBP2-22528]

By Jamshed Arslan, Pharm. D., PhD.

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The Ins and Outs of Survivin

Exosomes arise from the late endosomal compartment through inward budding of multivesicular bodies and may contain multiple proteins, lipids, DNA, RNAs and biomolecules of viruses/prions.

By Rachel M.A. Linger, Ph.D.

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Cancer Research

ednrb-endothelin-r-type-b

Rachel M.A. Linger

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Chromatin reader domains of DNMT-targeting protein, UHRF1, are responsible for cancerous DNA hypermethylation

Expression of DNMT2 in human colon tissue shows cytoplasmic and nuclear staining in glandular cells, IHC

By Jamshed Arslan, Pharm. D., PhD.

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Cancer Research

Immunohistochemistry

prostasin-prss8

Stemness is responsible for onset and metastasis of colorectal cancer

beta-Catenin expression in mouse colon, IHC

By Jamshed Arslan, Pharm. D., PhD.

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Cancer Research

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Success of combined IL-10 and IL-12 therapy in colon cancer depends on IFN-gamma and gut barrier integrity

IL10 receptor alpha expression in human colon carcinoma, IHC

By Jamshed Arslan, Pharm. D., PhD.

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Colorectal Cancer

Cytotoxic T cells

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