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Glucose

Deficiency of GluT1 leads to neurological problems while excess is involved in cancers

O-GlcNAc, Glucose Deprivation and Cancer

O-linked beta-N-acetylglucosamine (O-GlcNAc) is a sugar attachment to serine or threonine hydroxyl moieties on nuclear and cytoplasmic proteins. O-GlcNAc modified proteins are generally either cytoplasmic or nuclear proteins, and unlike asparagine-linked or mucin-type O-glycosylation, O-GlcNAc is not further processed into a complex oligosaccharide.